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人骨髓间充质干细胞成骨分化早期相关的长链非编码RNA的初步研究

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العنوان: 人骨髓间充质干细胞成骨分化早期相关的长链非编码RNA的初步研究
المصدر: Zhongshan Daxue xuebao. Yixue kexue ban, Vol 37 (2016)
بيانات النشر: Editorial Office of Journal of Sun Yat-sen University, 2016.
سنة النشر: 2016
المجموعة: LCC:Medicine (General)
مصطلحات موضوعية: 人骨髓间充质干细胞, 成骨分化早期, 长链非编码RNA, 生物信息学分析, Medicine (General), R5-920
الوصف: 摘 要:【目的】 筛选与人骨髓间充质干细胞(hMSC)成骨分化早期相关的长链非编码RNA(lncRNA),分析其对于hMSC成骨分化早期的影响?【方法】 将成骨诱导分化7 d前后的hMSC作为研究对象,利用Agilent lncRNA芯片技术筛选出成骨诱导分化前后表达量具有2倍差异的lncRNA,选取其中1条表达量差异较大的lncRNA利用UCSC Genome Browser分析此lncRNA邻近蛋白编码基因?【结果】 hMSC经过成骨分化诱导7 d后具有明显成骨细胞特征;Agilent lncRNA芯片技术筛选结果表明,hMSC成骨分化诱导7 d后表达上调的lncRNA有923条,表达下调的有993条;选择表达上调中表达量差异较大的1条lncRNA ENST00000585537.1,UCSC Genome Browser生物信息学分析显示其与MAPK蛋白相关?【结论】 hMSC成骨分化诱导7 d后lncRNA表达发生改变,部分表达差异较大的lncRNA可能通过与相关蛋白编码基因联系影响hMSC的早期成骨分化功能?
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: Chinese
تدمد: 1672-3554
Relation: http://xuebaoyx.sysu.edu.cn/zh/article/43571846/; https://doaj.org/toc/1672-3554
URL الوصول: https://doaj.org/article/32420b29bd454a90acfb46eba21733c7
رقم الانضمام: edsdoj.32420b29bd454a90acfb46eba21733c7
قاعدة البيانات: Directory of Open Access Journals
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