Academic Journal
In Silico Screening Accelerates Nanocarrier Design for Efficient mRNA Delivery
| العنوان: | In Silico Screening Accelerates Nanocarrier Design for Efficient mRNA Delivery |
|---|---|
| المؤلفون: | Tristan Henser‐Brownhill, Liam Martin, Parisa Samangouei, Aaqib Ladak, Marina Apostolidou, Benita Nagel, Albert Kwok |
| المصدر: | Advanced Science, Vol 11, Iss 30, Pp n/a-n/a (2024) |
| بيانات النشر: | Wiley, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Science |
| مصطلحات موضوعية: | drug delivery, LNP, machine learning, mRNA delivery, nanocarriers, nanoparticles, Science |
| الوصف: | Abstract Lipidic nanocarriers are a broad class of lipid‐based vectors with proven potential for packaging and delivering emerging nucleic acid therapeutics. An important early step in the clinical development cycle is large‐scale screening of diverse formulation libraries to assess particle quality and payload delivery efficiency. Due to the size of the screening space, this process can be both costly and time‐consuming. To address this, computational models capable of predicting clinically relevant physio‐chemical properties of dendrimer‐lipid nanocarriers, along with their mRNA payload delivery efficiency in human cells are developed. The models are then deployed on a large theoretical nanocarrier pool consisting of over 4.5 million formulations. Top predictions are synthesised for validation using cell‐based assays, leading to the discovery of a high quality, high performing, candidate. The methods reported here enable rapid, high‐throughput, in silico pre‐screening for high‐quality candidates, and have great potential to reduce the cost and time required to bring mRNA therapies to the clinic. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2198-3844 |
| Relation: | https://doaj.org/toc/2198-3844 |
| DOI: | 10.1002/advs.202401935 |
| URL الوصول: | https://doaj.org/article/2fa1401055a240eab5571bf70e2aea56 |
| رقم الانضمام: | edsdoj.2fa1401055a240eab5571bf70e2aea56 |
| قاعدة البيانات: | Directory of Open Access Journals |
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