Academic Journal
Clinical factors affecting the long-term survival of breast cancer patients
| العنوان: | Clinical factors affecting the long-term survival of breast cancer patients |
|---|---|
| المؤلفون: | Yong-Hui Li, Xiao-Ying Wang, Jun-Wei Shen, Lin-Lin Ma, Cui-Ping Wang, Kai He, Ding-Sheng Liu, Yan-Fei Li |
| المصدر: | Journal of International Medical Research, Vol 51 (2023) |
| بيانات النشر: | SAGE Publishing, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine (General) |
| مصطلحات موضوعية: | Medicine (General), R5-920 |
| الوصف: | Objective The average 5-year survival rate of breast cancer (BC) patients has been significantly prolonged with new therapeutic methods. However, their effects on BC patient long-term survival rates are unclear. Therefore, this study aimed to analyze the specific clinical factors that can affect BC long-term survival. Methods Here, we conducted a retrospective study and analyzed long-term survival using data of 3,240 BC patients from 1977 to 2005 from the Genotype-Tissue Expression (GTEx) database using the Kaplan–Meier method. Results Breast tumor size and stage were negatively correlated with long-term survival, but age showed no significant correlation. Estrogen receptor (ER) and progesterone receptor (PR) expression were each positively correlated with patient survival time, while ERBB2 receptor (HER2) expression was negatively correlated with survival time. Patients with high Nottingham prognostic index (NPI) values did not benefit from available therapies. Furthermore, breast-conserving surgery is more conducive to BC patient long-term survival than mastectomy. Conclusions Early detection and breast-conserving surgery may support long-term survival for BC patients. Elevated expression of ER and PR were both associated with longer patient survival time, while positive expression of HER2 showed the opposite trend. The long-term survival rates of patients with high NPI values can potentially be increased. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1473-2300 03000605 |
| Relation: | https://doaj.org/toc/1473-2300 |
| DOI: | 10.1177/03000605231164004 |
| URL الوصول: | https://doaj.org/article/2209fe472fc0408c8462f408b234b041 |
| رقم الانضمام: | edsdoj.2209fe472fc0408c8462f408b234b041 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | ResultId |
1 |
|---|---|
| Header |
edsdoj Directory of Open Access Journals edsdoj.2209fe472fc0408c8462f408b234b041 967 3 Academic Journal academicJournal 967.30224609375 |
| PLink |
https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsdoj&AN=edsdoj.2209fe472fc0408c8462f408b234b041&custid=s6537998&authtype=sso |
| FullText |
Array
(
[Availability] => 0
)
Array ( [0] => Array ( [Url] => https://doaj.org/article/2209fe472fc0408c8462f408b234b041 [Name] => EDS - DOAJ [Category] => fullText [Text] => View record in DOAJ [MouseOverText] => View record in DOAJ ) [1] => Array ( [Url] => https://resolver.ebscohost.com/openurl?custid=s6537998&groupid=main&authtype=ip,guest&sid=EBSCO:edsdoj&genre=article&issn=14732300&ISBN=&volume=51&issue=&date=20230301&spage=&pages=&title=Journal of International Medical Research&atitle=Clinical%20factors%20affecting%20the%20long-term%20survival%20of%20breast%20cancer%20patients&id=DOI:10.1177/03000605231164004 [Name] => Full Text Finder (s6537998api) [Category] => fullText [Text] => Full Text Finder [Icon] => https://imageserver.ebscohost.com/branding/images/FTF.gif [MouseOverText] => Full Text Finder ) ) |
| Items |
Array
(
[Name] => Title
[Label] => Title
[Group] => Ti
[Data] => Clinical factors affecting the long-term survival of breast cancer patients
)
Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => <searchLink fieldCode="AR" term="%22Yong-Hui+Li%22">Yong-Hui Li</searchLink><br /><searchLink fieldCode="AR" term="%22Xiao-Ying+Wang%22">Xiao-Ying Wang</searchLink><br /><searchLink fieldCode="AR" term="%22Jun-Wei+Shen%22">Jun-Wei Shen</searchLink><br /><searchLink fieldCode="AR" term="%22Lin-Lin+Ma%22">Lin-Lin Ma</searchLink><br /><searchLink fieldCode="AR" term="%22Cui-Ping+Wang%22">Cui-Ping Wang</searchLink><br /><searchLink fieldCode="AR" term="%22Kai+He%22">Kai He</searchLink><br /><searchLink fieldCode="AR" term="%22Ding-Sheng+Liu%22">Ding-Sheng Liu</searchLink><br /><searchLink fieldCode="AR" term="%22Yan-Fei+Li%22">Yan-Fei Li</searchLink> ) Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => Journal of International Medical Research, Vol 51 (2023) ) Array ( [Name] => Publisher [Label] => Publisher Information [Group] => PubInfo [Data] => SAGE Publishing, 2023. ) Array ( [Name] => DatePubCY [Label] => Publication Year [Group] => Date [Data] => 2023 ) Array ( [Name] => Subset [Label] => Collection [Group] => HoldingsInfo [Data] => LCC:Medicine (General) ) Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => <searchLink fieldCode="DE" term="%22Medicine+%28General%29%22">Medicine (General)</searchLink><br /><searchLink fieldCode="DE" term="%22R5-920%22">R5-920</searchLink> ) Array ( [Name] => Abstract [Label] => Description [Group] => Ab [Data] => Objective The average 5-year survival rate of breast cancer (BC) patients has been significantly prolonged with new therapeutic methods. However, their effects on BC patient long-term survival rates are unclear. Therefore, this study aimed to analyze the specific clinical factors that can affect BC long-term survival. Methods Here, we conducted a retrospective study and analyzed long-term survival using data of 3,240 BC patients from 1977 to 2005 from the Genotype-Tissue Expression (GTEx) database using the Kaplan–Meier method. Results Breast tumor size and stage were negatively correlated with long-term survival, but age showed no significant correlation. Estrogen receptor (ER) and progesterone receptor (PR) expression were each positively correlated with patient survival time, while ERBB2 receptor (HER2) expression was negatively correlated with survival time. Patients with high Nottingham prognostic index (NPI) values did not benefit from available therapies. Furthermore, breast-conserving surgery is more conducive to BC patient long-term survival than mastectomy. Conclusions Early detection and breast-conserving surgery may support long-term survival for BC patients. Elevated expression of ER and PR were both associated with longer patient survival time, while positive expression of HER2 showed the opposite trend. The long-term survival rates of patients with high NPI values can potentially be increased. ) Array ( [Name] => TypeDocument [Label] => Document Type [Group] => TypDoc [Data] => article ) Array ( [Name] => Format [Label] => File Description [Group] => SrcInfo [Data] => electronic resource ) Array ( [Name] => Language [Label] => Language [Group] => Lang [Data] => English ) Array ( [Name] => ISSN [Label] => ISSN [Group] => ISSN [Data] => 1473-2300<br />03000605 ) Array ( [Name] => NoteTitleSource [Label] => Relation [Group] => SrcInfo [Data] => https://doaj.org/toc/1473-2300 ) Array ( [Name] => DOI [Label] => DOI [Group] => ID [Data] => 10.1177/03000605231164004 ) Array ( [Name] => URL [Label] => Access URL [Group] => URL [Data] => <link linkTarget="URL" linkTerm="https://doaj.org/article/2209fe472fc0408c8462f408b234b041" linkWindow="_blank">https://doaj.org/article/2209fe472fc0408c8462f408b234b041</link> ) Array ( [Name] => AN [Label] => Accession Number [Group] => ID [Data] => edsdoj.2209fe472fc0408c8462f408b234b041 ) |
| RecordInfo |
Array
(
[BibEntity] => Array
(
[Identifiers] => Array
(
[0] => Array
(
[Type] => doi
[Value] => 10.1177/03000605231164004
)
)
[Languages] => Array
(
[0] => Array
(
[Text] => English
)
)
[Subjects] => Array
(
[0] => Array
(
[SubjectFull] => Medicine (General)
[Type] => general
)
[1] => Array
(
[SubjectFull] => R5-920
[Type] => general
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Clinical factors affecting the long-term survival of breast cancer patients
[Type] => main
)
)
)
[BibRelationships] => Array
(
[HasContributorRelationships] => Array
(
[0] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Yong-Hui Li
)
)
)
[1] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Xiao-Ying Wang
)
)
)
[2] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Jun-Wei Shen
)
)
)
[3] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Lin-Lin Ma
)
)
)
[4] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Cui-Ping Wang
)
)
)
[5] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Kai He
)
)
)
[6] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Ding-Sheng Liu
)
)
)
[7] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Yan-Fei Li
)
)
)
)
[IsPartOfRelationships] => Array
(
[0] => Array
(
[BibEntity] => Array
(
[Dates] => Array
(
[0] => Array
(
[D] => 01
[M] => 03
[Type] => published
[Y] => 2023
)
)
[Identifiers] => Array
(
[0] => Array
(
[Type] => issn-print
[Value] => 14732300
)
[1] => Array
(
[Type] => issn-print
[Value] => 03000605
)
)
[Numbering] => Array
(
[0] => Array
(
[Type] => volume
[Value] => 51
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Journal of International Medical Research
[Type] => main
)
)
)
)
)
)
)
|
| IllustrationInfo |