Academic Journal
Biomarker identification using dynamic time warping analysis: a longitudinal cohort study of patients with COVID-19 in a UK tertiary hospital
| العنوان: | Biomarker identification using dynamic time warping analysis: a longitudinal cohort study of patients with COVID-19 in a UK tertiary hospital |
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| المؤلفون: | Alastair Watson, Hang Phan, Florina Borca, Sarah Williams, Tom Wilkinson, Hannah Burke, Anna Freeman, Ahilanandan Dushianthan, Michael Celinski, James Batchelor, Natasha Sheard, Paul Fitzpatrick, Dónal Landers, André Freitas, Paul O’Regan, Oskar Wysocki |
| المصدر: | BMJ Open, Vol 12, Iss 2 (2022) |
| بيانات النشر: | BMJ Publishing Group, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | Medicine |
| الوصف: | Objectives COVID-19 is a heterogeneous disease, and many reports have described variations in demographic, biochemical and clinical features at presentation influencing overall hospital mortality. However, there is little information regarding longitudinal changes in laboratory prognostic variables in relation to disease progression in hospitalised patients with COVID-19.Design and setting This retrospective observational report describes disease progression from symptom onset, to admission to hospital, clinical response and discharge/death among patients with COVID-19 at a tertiary centre in South East England.Participants Six hundred and fifty-one patients treated for SARS-CoV-2 between March and September 2020 were included in this analysis. Ethical approval was obtained from the HRA Specific Review Board (REC 20/HRA/2986) for waiver of informed consent.Results The majority of patients presented within 1 week of symptom onset. The lowest risk patients had low mortality (1/45, 2%), and most were discharged within 1 week after admission (30/45, 67%). The highest risk patients, as determined by the 4C mortality score predictor, had high mortality (27/29, 93%), with most dying within 1 week after admission (22/29, 76%). Consistent with previous reports, most patients presented with high levels of C reactive protein (CRP) (67% of patients >50 mg/L), D-dimer (98%>upper limit of normal (ULN)), ferritin (65%>ULN), lactate dehydrogenase (90%>ULN) and low lymphocyte counts (81% |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2044-6055 |
| Relation: | https://bmjopen.bmj.com/content/12/2/e050331.full; https://doaj.org/toc/2044-6055 |
| DOI: | 10.1136/bmjopen-2021-050331 |
| URL الوصول: | https://doaj.org/article/219b6cd5397b477c8b797cbe1b594cde |
| رقم الانضمام: | edsdoj.219b6cd5397b477c8b797cbe1b594cde |
| قاعدة البيانات: | Directory of Open Access Journals |
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