Academic Journal
De novo genome assembly depicts the immune genomic characteristics of cattle
| العنوان: | De novo genome assembly depicts the immune genomic characteristics of cattle |
|---|---|
| المؤلفون: | Ting-Ting Li, Tian Xia, Jia-Qi Wu, Hao Hong, Zhao-Lin Sun, Ming Wang, Fang-Rong Ding, Jing Wang, Shuai Jiang, Jin Li, Jie Pan, Guang Yang, Jian-Nan Feng, Yun-Ping Dai, Xue-Min Zhang, Tao Zhou, Tao Li |
| المصدر: | Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023) |
| بيانات النشر: | Nature Portfolio, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Science |
| مصطلحات موضوعية: | Science |
| الوصف: | Abstract Immunogenomic loci remain poorly understood because of their genetic complexity and size. Here, we report the de novo assembly of a cattle genome and provide a detailed annotation of the immunogenomic loci. The assembled genome contains 143 contigs (N50 ~ 74.0 Mb). In contrast to the current reference genome (ARS-UCD1.2), 156 gaps are closed and 467 scaffolds are located in our assembly. Importantly, the immunogenomic regions, including three immunoglobulin (IG) loci, four T-cell receptor (TR) loci, and the major histocompatibility complex (MHC) locus, are seamlessly assembled and precisely annotated. With the characterization of 258 IG genes and 657 TR genes distributed across seven genomic loci, we present a detailed depiction of immune gene diversity in cattle. Moreover, the MHC gene structures are integrally revealed with properly phased haplotypes. Together, our work describes a more complete cattle genome, and provides a comprehensive view of its complex immune-genome. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2041-1723 |
| Relation: | https://doaj.org/toc/2041-1723 |
| DOI: | 10.1038/s41467-023-42161-1 |
| URL الوصول: | https://doaj.org/article/20de93a1ead74e498aad5f5f9790b473 |
| رقم الانضمام: | edsdoj.20de93a1ead74e498aad5f5f9790b473 |
| قاعدة البيانات: | Directory of Open Access Journals |
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