Academic Journal
Lysosome-related organelles promote stress and immune responses in C. elegans
العنوان: | Lysosome-related organelles promote stress and immune responses in C. elegans |
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المؤلفون: | Gábor Hajdú, Milán Somogyvári, Péter Csermely, Csaba Sőti |
المصدر: | Communications Biology, Vol 6, Iss 1, Pp 1-17 (2023) |
بيانات النشر: | Nature Portfolio, 2023. |
سنة النشر: | 2023 |
المجموعة: | LCC:Biology (General) |
مصطلحات موضوعية: | Biology (General), QH301-705.5 |
الوصف: | Abstract Lysosome-related organelles (LROs) play diverse roles and their dysfunction causes immunodeficiency. However, their primordial functions remain unclear. Here, we report that C. elegans LROs (gut granules) promote organismal defenses against various stresses. We find that toxic benzaldehyde exposure induces LRO autofluorescence, stimulates the expression of LRO-specific genes and enhances LRO transport capacity as well as increases tolerance to benzaldehyde, heat and oxidative stresses, while these responses are impaired in glo-1/Rab32 and pgp-2 ABC transporter LRO biogenesis mutants. Benzaldehyde upregulates glo-1- and pgp-2-dependent expression of heat shock, detoxification and antimicrobial effector genes, which requires daf-16/FOXO and/or pmk-1/p38MAPK. Finally, benzaldehyde preconditioning increases resistance against Pseudomonas aeruginosa PA14 in a glo-1- and pgp-2-dependent manner, and PA14 infection leads to the deposition of fluorescent metabolites in LROs and induction of LRO genes. Our study suggests that LROs may play a role in systemic responses to stresses and in pathogen resistance. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 2399-3642 |
Relation: | https://doaj.org/toc/2399-3642 |
DOI: | 10.1038/s42003-023-05246-7 |
URL الوصول: | https://doaj.org/article/2065cd3c21bc4202a9b44ec67886bcf1 |
رقم الانضمام: | edsdoj.2065cd3c21bc4202a9b44ec67886bcf1 |
قاعدة البيانات: | Directory of Open Access Journals |
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