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ADIPOQ rs2241766 SNP as protective marker against DIBC development in Mexican population.

التفاصيل البيبلوغرافية
العنوان: ADIPOQ rs2241766 SNP as protective marker against DIBC development in Mexican population.
المؤلفون: Nelly Margarita Macías-Gómez, María Carmen Hernández-Terrones, Angélica Araceli Ramírez-Guerrero, Evelia Leal-Ugarte, Melva Gutiérrez-Angulo, Jorge Peregrina-Sandoval
المصدر: PLoS ONE, Vol 14, Iss 3, p e0214080 (2019)
بيانات النشر: Public Library of Science (PLoS), 2019.
سنة النشر: 2019
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: BACKGROUND:Adiponectin protein and some variations in its gene, ADIPOQ have recently been associated with cancer because they regulate glucose and lipid metabolism as well as anti-apoptotic and anti-inflammatory proteins. AIM:The aim of this study was to analyse the relationship between selected biochemical markers, anthropometric indices and ADIPOQ rs2241766 and rs1501299 SNPs in ductal infiltrating breast cancer (DIBC) in a Mexican population. METHODS:This cross-sectional study included 64 DIBC patients and 167 healthy women. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis was performed to identify the genotypes of the rs2241766 (exon 2) and rs1501299 (intron 2) ADIPOQ polymorphisms. Corporal composition and biochemical markers included body mass index (BMI), waist circumference (WC), hip circumference (HC), waist-hip ratio (WHR), glucose, cholesterol, triglycerides and high- and low-density lipoprotein cholesterol. RESULTS:Patients with DIBC had higher serum glucose, WC and WHR than controls. Intergroup differences in allele and genotype frequencies were found for both polymorphisms (P < 0.05). Patients carrying the rs2241766 TT and TG genotypes had higher values of WC, HC and WHR, but only TG carriers had higher levels of glucose. For the SNP rs1501299, carriers of the GG genotype in the DIBC group had higher values of glucose, WC, HC and WHR than the respective control group. CONCLUSIONS:These results suggest that WC, HC and WHR are better predictors of DIBC than BMI. The ADIPOQ SNP rs2241766 emerges as a protective factor, whereas rs1501299 is a risk factor for DIBC development in a Mexican population.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0214080
URL الوصول: https://doaj.org/article/c1e4434319b843338ec60651acd63200
رقم الانضمام: edsdoj.1e4434319b843338ec60651acd63200
قاعدة البيانات: Directory of Open Access Journals
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