Academic Journal
Regulatory T lymphocytes are associated with less aggressive histologic features in microsatellite-unstable colorectal cancers.
| العنوان: | Regulatory T lymphocytes are associated with less aggressive histologic features in microsatellite-unstable colorectal cancers. |
|---|---|
| المؤلفون: | David Tougeron, Pauline Maby, Nicolas Elie, Emilie Fauquembergue, Florence Le Pessot, Marie Cornic, Jean-Christophe Sabourin, Pierre Michel, Thierry Frébourg, Jean-Baptiste Latouche |
| المصدر: | PLoS ONE, Vol 8, Iss 4, p e61001 (2013) |
| بيانات النشر: | Public Library of Science (PLoS), 2013. |
| سنة النشر: | 2013 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | BACKGROUND: Colorectal cancers (CRCs) with microsatellite instability (MSI) are associated with a good prognosis and a high density of tumor-infiltrating lymphocytes (TILs). We have undertaken to determine the link between TIL densities and MSI CRC histologic features. PATIENTS AND METHODS: Using tissue microarrays, T-cell sub-population infiltration, including T cells (CD3), cytotoxic T cells (CD8) and regulatory T cells (FoxP3) were studied in 86 MSI CRCs. We separately analyzed TILs of the stromal and epithelial compartments in the tumor center, the tumoral invasion margin and associated normal tissue. RESULTS: For FoxP3+ TIL density in the tumor center stromal compartment, we found a strong negative correlation with T4 stage (p = 0.01), node invasion (p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1932-6203 |
| Relation: | http://europepmc.org/articles/PMC3626697?pdf=render; https://doaj.org/toc/1932-6203 |
| DOI: | 10.1371/journal.pone.0061001 |
| URL الوصول: | https://doaj.org/article/1deeba460be04e0ab5c98566886e6ab2 |
| رقم الانضمام: | edsdoj.1deeba460be04e0ab5c98566886e6ab2 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19326203 |
|---|---|
| DOI: | 10.1371/journal.pone.0061001 |