Academic Journal
Comparison Evaluation of the Biological Effects of Sterigmatocystin and Aflatoxin B1 Utilizing SOS-Chromotest and a Novel Zebrafish (Danio rerio) Embryo Microinjection Method
| العنوان: | Comparison Evaluation of the Biological Effects of Sterigmatocystin and Aflatoxin B1 Utilizing SOS-Chromotest and a Novel Zebrafish (Danio rerio) Embryo Microinjection Method |
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| المؤلفون: | Zsolt Csenki, Anita Risa, Dorottya Sárkány, Edina Garai, Ildikó Bata-Vidács, Erzsébet Baka, András Szekeres, Mónika Varga, András Ács, Jeffrey Griffitts, Katalin Bakos, Illés Bock, István Szabó, Balázs Kriszt, Béla Urbányi, József Kukolya |
| المصدر: | Toxins, Vol 14, Iss 4, p 252 (2022) |
| بيانات النشر: | MDPI AG, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | mycotoxin, teratogenicity, MAS activation, Medicine |
| الوصف: | Aflatoxin B1 (AFB1) is a potent mycotoxin and natural carcinogen. The primary producers of AFB1 are Aspergillus flavus and A. parasiticus. Sterigmatocystin (STC), another mycotoxin, shares its biosynthetic pathway with aflatoxins. While there are abundant data on the biological effects of AFB1, STC is not well characterised. According to published data, AFB1 is more harmful to biological systems than STC. It has been suggested that STC is about one-tenth as potent a mutagen as AFB1 as measured by the Ames test. In this research, the biological effects of S9 rat liver homogenate-activated and non-activated STC and AFB1 were compared using two different biomonitoring systems, SOS-Chromotest and a recently developed microinjection zebrafish embryo method. When comparing the treatments, activated STC caused the highest mortality and number of DNA strand breaks across all injected volumes. Based on the E. coli SOS-Chromotest, the two toxins exerted the same genotoxicities. Moreover, according to the newly developed zebrafish microinjection method, STC appeared more toxic than AFB1. The scarce information correlating AFB1 and STC toxicity suggests that AFB1 is a more potent genotoxin than STC. Our findings contradict this assumption and illustrate the need for more complex biomonitoring systems for mycotoxin risk assessment. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2072-6651 |
| Relation: | https://www.mdpi.com/2072-6651/14/4/252; https://doaj.org/toc/2072-6651 |
| DOI: | 10.3390/toxins14040252 |
| URL الوصول: | https://doaj.org/article/1c5421c695b74185b30ca9992778319f |
| رقم الانضمام: | edsdoj.1c5421c695b74185b30ca9992778319f |
| قاعدة البيانات: | Directory of Open Access Journals |
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