Academic Journal
Diagnostic Role of Cartridge-Based Nucleic Acid Amplification Test (CB-NAAT) in Both Pulmonary and Extra-Pulmonary Pediatric Tuberculosis: A Hospital-Based Study
| العنوان: | Diagnostic Role of Cartridge-Based Nucleic Acid Amplification Test (CB-NAAT) in Both Pulmonary and Extra-Pulmonary Pediatric Tuberculosis: A Hospital-Based Study |
|---|---|
| المؤلفون: | Radhika Uppal, Pooja Bharti, Deepak Sharma, Sanjana Sharma |
| المصدر: | JK Science, Vol 26, Iss 1 (2024) |
| بيانات النشر: | Dr. Annil Mahajan, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Medicine (General) LCC:Internal medicine |
| مصطلحات موضوعية: | CB-NAAT, Tuberculosis, Pediatric, Pulmonary, Extra-pulmonary, Medicine (General), R5-920, Internal medicine, RC31-1245 |
| الوصف: | Background: Early diagnosis of pediatric tuberculosis (TB) still remains a challenge due to the paucibacillary nature of the disease. Objectives: To assess the role of CB-NAAT in diagnosing pulmonary and extrapulmonary tuberculosis as compared to AFB smear and Mycobacterium tuberculosis culture in clinically diagnosed pediatric tuberculosis cases. Study design: Hospital-based prospective study. Methods: A total of142 patients with strong clinical suspicion of pulmonary or extra-pulmonary tuberculosis were enrolled over a period of two years and then results of CB-NAAT were compared to conventional methods (culture/ AFB smear) on follow-up. Results: In subjects who had clinically diagnosed tuberculosis, culture was positive in 18.9% of cases, AFB smear was positive in only 12.1% whereas CB-NAAT was positive in 55.4% of subjects. The sensitivity, specificity, PPV, and NPV of CB-NAAT in patients with culture proven tuberculosis were100%, 83.3%, 47.5%, and 100% respectively with a diagnostic accuracy of 93.3%. and 60%, 100%, 100%, and 65.8% respectively with a diagnostic accuracy of 80.2% in clinically diagnosed pulmonary cases. Conclusion: CB-NAAT has true diagnostic potential with good sensitivity in confirmed cases and significantly better sensitivity than conventional methods in clinically diagnosed cases. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0972-1177 |
| Relation: | https://journal.jkscience.org/index.php/JK-Science/article/view/242; https://doaj.org/toc/0972-1177 |
| URL الوصول: | https://doaj.org/article/1b7b62c6fd45478eb7f6c2a6d38736e7 |
| رقم الانضمام: | edsdoj.1b7b62c6fd45478eb7f6c2a6d38736e7 |
| قاعدة البيانات: | Directory of Open Access Journals |
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