Academic Journal
Comparison of diagnostic capability of macular ganglion cell complex and retinal nerve fiber layer among primary open angle glaucoma, ocular hypertension, and normal population using Fourier-domain optical coherence tomography and determining their functional correlation in Indian population
| العنوان: | Comparison of diagnostic capability of macular ganglion cell complex and retinal nerve fiber layer among primary open angle glaucoma, ocular hypertension, and normal population using Fourier-domain optical coherence tomography and determining their functional correlation in Indian population |
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| المؤلفون: | Nabanita Barua, Chitra Sitaraman, Sonu Goel, Chandana Chakraborti, Sonai Mukherjee, Hemandra Parashar |
| المصدر: | Indian Journal of Ophthalmology, Vol 64, Iss 4, Pp 296-302 (2016) |
| بيانات النشر: | Wolters Kluwer Medknow Publications, 2016. |
| سنة النشر: | 2016 |
| المجموعة: | LCC:Ophthalmology |
| مصطلحات موضوعية: | Early diagnosis of glaucoma, Fourier-domain-optical coherence tomography, ganglion cell complex, retinal nerve fiber layer, Ophthalmology, RE1-994 |
| الوصف: | Context: Analysis of diagnostic ability of macular ganglionic cell complex and retinal nerve fiber layer (RNFL) in glaucoma. Aim: To correlate functional and structural parameters and comparing predictive value of each of the structural parameters using Fourier-domain (FD) optical coherence tomography (OCT) among primary open angle glaucoma (POAG) and ocular hypertension (OHT) versus normal population. Setting and Design: Single centric, cross-sectional study done in 234 eyes. Materials and Methods: Patients were enrolled in three groups: POAG, ocular hypertensive and normal (40 patients in each group). After comprehensive ophthalmological examination, patients underwent standard automated perimetry and FD-OCT scan in optic nerve head and ganglion cell mode. The relationship was assessed by correlating ganglion cell complex (GCC) parameters with mean deviation. Results were compared with RNFL parameters. Statistical Analysis: Data were analyzed with SPSS, analysis of variance, t-test, Pearson′s coefficient, and receiver operating curve. Results: All parameters showed strong correlation with visual field (P < 0.001). Inferior GCC had highest area under curve (AUC) for detecting glaucoma (0.827) in POAG from normal population. However, the difference was not statistically significant (P > 0.5) when compared with other parameters. None of the parameters showed significant diagnostic capability to detect OHT from normal population. In diagnosing early glaucoma from OHT and normal population, only inferior GCC had statistically significant AUC value (0.715). Conclusion: In this study, GCC and RNFL parameters showed equal predictive capability in perimetric versus normal group. In early stage, inferior GCC was the best parameter. In OHT population, single day cross-sectional imaging was not valuable. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0301-4738 1998-3689 |
| Relation: | http://www.ijo.in/article.asp?issn=0301-4738;year=2016;volume=64;issue=4;spage=296;epage=302;aulast=Barua; https://doaj.org/toc/0301-4738; https://doaj.org/toc/1998-3689 |
| DOI: | 10.4103/0301-4738.182941 |
| URL الوصول: | https://doaj.org/article/12ebbdefa3c24d929502f00e8dc0a3e3 |
| رقم الانضمام: | edsdoj.12ebbdefa3c24d929502f00e8dc0a3e3 |
| قاعدة البيانات: | Directory of Open Access Journals |
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