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Protective effect of four Mexican plants against CCl4-induced damage on the Huh7 human hepatoma cell line

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العنوان: Protective effect of four Mexican plants against CCl4-induced damage on the Huh7 human hepatoma cell line
المؤلفون: Liliana Torres-González, Linda Elsa Muñoz-Espinosa, Ana María Rivas-Estilla, Karina Trujillo-Murillo, Ricardo Salazar-Aranda, Noemi Waksman De Torres, Paula Cordero-Pérez
المصدر: Annals of Hepatology, Vol 10, Iss 1, Pp 73-79 (2011)
بيانات النشر: Elsevier, 2011.
سنة النشر: 2011
المجموعة: LCC:Specialties of internal medicine
مصطلحات موضوعية: Centaurea americana, Krameria ramosissima, Juglans mollis, Turnera diffusa, Specialties of internal medicine, RC581-951
الوصف: Background. Centaurea americana, Krameria ramosissima, Juglans mollis and Turnera diffusa are used by traditional healers in the northeastern region of Mexico to protect against liver damage. However, the hepatoprotective properties of these plants have not been investigated scientifically. This study reports on the protective effects of these plants using an in vitro assay.Material and methods. Extracts of plants were tested for antioxidant activity using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging method. The effects of extracts from these plants on a human hepatoma cell line (Huh7) were evaluated according to cell viability and aspartate aminotransferase and malondialdehyde levels before and after exposure of the cells to carbon tetrachloride (CCl4).Results. All extracts reduced DPPH levels by more than 50%. C. americana flower and stem/leaf extracts, the aerial part of T. diffusa, and the nut, leaf and bark of J. mollis extracts were used to assess hepatoprotective activity. The extract of the aerial part of K. ramosissima was toxic. Pretreatment of Huh7 cells with extracts from the flower of C. americana (FCA), the stem/leaf fraction of C. americana (S/LCA), the leaf of J. mollis (LJM) and the bark of J. mollis (BJM) prior to the CCl4 challenge, protected against CCl4-induced liver damage, as evidenced by a significant decrease in the activity of the medium enzyme. The FCA, S/LCA, LJM and BJM extracts showed significant antilipid peroxidant effects in vitro. In conclusion, the hepatoprotective effects of the FCA, S/LCA, LJM and BJM extracts observed in this study may result from their antioxidative properties.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1665-2681
Relation: http://www.sciencedirect.com/science/article/pii/S166526811931590X; https://doaj.org/toc/1665-2681
DOI: 10.1016/S1665-2681(19)31590-X
URL الوصول: https://doaj.org/article/12c57ecca6114144b6d02188a0371a94
رقم الانضمام: edsdoj.12c57ecca6114144b6d02188a0371a94
قاعدة البيانات: Directory of Open Access Journals
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