Academic Journal
The utility of serial procalcitonin measurements in addition to pneumonia severity scores in hospitalised community-acquired pneumonia: A multicentre, prospective study
| العنوان: | The utility of serial procalcitonin measurements in addition to pneumonia severity scores in hospitalised community-acquired pneumonia: A multicentre, prospective study |
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| المؤلفون: | Akihiro Ito, Isao Ito, Daiki Inoue, Satoshi Marumo, Tetsuya Ueda, Hiroaki Nakagawa, Masato Taki, Atsushi Nakagawa, Shuji Tatsumi, Takashi Nishimura, Tetsuhiro Shiota, Tadashi Ishida |
| المصدر: | International Journal of Infectious Diseases, Vol 92, Iss , Pp 228-233 (2020) |
| بيانات النشر: | Elsevier, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Infectious and parasitic diseases |
| مصطلحات موضوعية: | Infectious and parasitic diseases, RC109-216 |
| الوصف: | Objectives: The usefulness of serial procalcitonin (PCT) measurements for predicting the prognosis and treatment efficacy for hospitalised community-acquired pneumonia (CAP) patients was investigated. Methods: This prospective, multicentre, cohort study enrolled consecutive CAP patients who were hospitalised at 10 hospitals in western Japan from September 2013 to September 2016. PCT and C-reactive protein (CRP) were measured on admission (PCT D1 and CRP D1), within 48–72 h after admission (PCT D3 and CRP D3), and within 144–192 h after admission. CURB-65 and the Pneumonia Severity Index (PSI) were assessed on admission. The primary outcome was 30-day mortality; secondary outcomes were early and late treatment failure rates. Results: A total of 710 patients were included. The 30-day mortality rate was 3.1%. On multivariate analysis, only PCT D3/D1 ratio >1 [odds ratio (95% confidence interval): 4.33 (1.46–12.82),P = 0.008] and PSI [odds ratio (95% confidence interval): 2.32 (1.07–5.03), P = 0.03] were significant prognostic factors. Regarding treatment efficacy, PCT D3/D1 >1 was a significant predictor of early treatment failure on multivariate analysis. PCT D3/D1 with the PSI significantly improved the prognostic accuracy over that of the PSI alone. Conclusions: PCT should be measured consecutively, not only on admission, to predict the prognosis and treatment efficacy in CAP. Keywords: Biomarker, C-reactive protein, Pneumonia, Procalcitonin, Prognosis |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1201-9712 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S1201971220300205; https://doaj.org/toc/1201-9712 |
| DOI: | 10.1016/j.ijid.2020.01.018 |
| URL الوصول: | https://doaj.org/article/109c1aa0f9ca4f39ae310faf6ed944e2 |
| رقم الانضمام: | edsdoj.109c1aa0f9ca4f39ae310faf6ed944e2 |
| قاعدة البيانات: | Directory of Open Access Journals |
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