Academic Journal
Long non-coding RNA NRSN2-AS1 promotes ovarian cancer progression through targeting PTK2/β-catenin pathway
| العنوان: | Long non-coding RNA NRSN2-AS1 promotes ovarian cancer progression through targeting PTK2/β-catenin pathway |
|---|---|
| المؤلفون: | Yi-Bo Wu, Shen-Yi Li, Jin-Yan Liu, Jia-Jia Xue, Jin-Fu Xu, Ting Chen, Tian-Yue Cao, Hui Zhou, Tian-Tian Wu, Chun-Lin Dong, Wei-Feng Qian, Long-Wei Qiao, Shun-Yu Hou, Ting Wang, Cong Shen |
| المصدر: | Cell Death and Disease, Vol 14, Iss 10, Pp 1-14 (2023) |
| بيانات النشر: | Nature Publishing Group, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Cytology |
| مصطلحات موضوعية: | Cytology, QH573-671 |
| الوصف: | Abstract As a common malignant tumor among women, ovarian cancer poses a serious threat to their health. This study demonstrates that long non-coding RNA NRSN2-AS1 is over-expressed in ovarian cancer tissues using patient sample and tissue microarrays. In addition, NRSN2-AS1 is shown to promote ovarian cancer cell proliferation and metastasis both in vitro and in vivo. Mechanistically, NRSN2-AS1 stabilizes protein tyrosine kinase 2 (PTK2) to activate the β-catenin pathway via repressing MG-53-mediated ubiquitinated degradation of PTK2, thereby facilitating ovarian cancer progression. Rescue experiments verify the function of the NRSN2-AS1/PTK2/β-catenin axis and the effects of MG53 on this axis in ovarian cancer cells. In conclusion, this study demonstrates the key role of the NRSN2-AS1/PTK2/β-catenin axis for the first time and explores its potential clinical applications in ovarian cancer. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2041-4889 |
| Relation: | https://doaj.org/toc/2041-4889 |
| DOI: | 10.1038/s41419-023-06214-z |
| URL الوصول: | https://doaj.org/article/0e028d23df334f8e8a0e9fd27695a516 |
| رقم الانضمام: | edsdoj.0e028d23df334f8e8a0e9fd27695a516 |
| قاعدة البيانات: | Directory of Open Access Journals |
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