Academic Journal
أعرض في EDS

Association between eNOS rs1799983 polymorphism and hypertension: a meta-analysis involving 14,185 cases and 13,407 controls

التفاصيل البيبلوغرافية
العنوان: Association between eNOS rs1799983 polymorphism and hypertension: a meta-analysis involving 14,185 cases and 13,407 controls
المؤلفون: Jikang Shi, Siyu Liu, Yanbo Guo, Sainan Liu, Jiayi Xu, Lingfeng Pan, Yueyang Hu, Yawen Liu, Yi Cheng
المصدر: BMC Cardiovascular Disorders, Vol 21, Iss 1, Pp 1-11 (2021)
بيانات النشر: BMC, 2021.
سنة النشر: 2021
المجموعة: LCC:Diseases of the circulatory (Cardiovascular) system
مصطلحات موضوعية: Hypertension, eNOS, rs1799983, Polymorphism, Meta-analysis, Diseases of the circulatory (Cardiovascular) system, RC666-701
الوصف: Abstract Background Essential hypertension is a complex disease determined by the interaction of genetic and environmental factors, eNOS is considered to be one of the susceptible genes for hypertension. Our study aimed to evaluate the association between eNOS rs1799983 polymorphism and hypertension, and to provide evidence for the etiology of hypertension. Methods Case–control studies of eNOS rs1799983 polymorphism and hypertension were included by searching PubMed, Embase, Web of Science, Medline, Scopus, WanFang datebase, Vip datebase, and CNKI database according to PRISMA guideline. Eligible data were extracted and pooled, and were analyzed using R software based on five different genetic models. Results A total of 60 eligible articles involving 14,185 cases and 13,407 controls were finally selected. We found significant association between eNOS rs1799983 polymorphism and hypertension under any genetic model (T vs G: OR = 1.44, 95% CI 1.26–1.63; GT vs GG: OR 1.34, 95% CI 1.18–1.52; TT vs GG: OR 1.80, 95% CI 1.41–2.31; GT + TT vs GG: OR 1.42, 95% CI 1.25–1.63; TT vs GG + GT: OR 1.68, 95% CI 1.35–2.08; GT vs GG + TT: OR 1.24, 95% CI 1.11–1.40). Conclusions We found that eNOS rs1799983 polymorphism is associated with the increased risk of hypertension under any genetic model. Moreover, investigations of gene–gene and gene-environment interactions are needed to give more insight into the association between eNOS rs1799983 polymorphism and hypertension.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1471-2261
Relation: https://doaj.org/toc/1471-2261
DOI: 10.1186/s12872-021-02192-2
URL الوصول: https://doaj.org/article/0529d6105d0b48ab9aafd1245c96085b
رقم الانضمام: edsdoj.0529d6105d0b48ab9aafd1245c96085b
قاعدة البيانات: Directory of Open Access Journals
ResultId 1
Header edsdoj
Directory of Open Access Journals
edsdoj.0529d6105d0b48ab9aafd1245c96085b
952
3
Academic Journal
academicJournal
951.913452148438
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsdoj&AN=edsdoj.0529d6105d0b48ab9aafd1245c96085b&custid=s6537998&authtype=sso
FullText Array ( [Availability] => 0 )
Array ( [0] => Array ( [Url] => https://doaj.org/article/0529d6105d0b48ab9aafd1245c96085b [Name] => EDS - DOAJ [Category] => fullText [Text] => View record in DOAJ [MouseOverText] => View record in DOAJ ) [1] => Array ( [Url] => https://resolver.ebscohost.com/openurl?custid=s6537998&groupid=main&authtype=ip,guest&sid=EBSCO:edsdoj&genre=article&issn=14712261&ISBN=&volume=21&issue=1&date=20210801&spage=1&pages=1-11&title=BMC Cardiovascular Disorders&atitle=Association%20between%20eNOS%20rs1799983%20polymorphism%20and%20hypertension%3A%20a%20meta-analysis%20involving%2014%2C185%20cases%20and%2013%2C407%20controls&id=DOI:10.1186/s12872-021-02192-2 [Name] => Full Text Finder (s6537998api) [Category] => fullText [Text] => Full Text Finder [Icon] => https://imageserver.ebscohost.com/branding/images/FTF.gif [MouseOverText] => Full Text Finder ) )
Items Array ( [Name] => Title [Label] => Title [Group] => Ti [Data] => Association between eNOS rs1799983 polymorphism and hypertension: a meta-analysis involving 14,185 cases and 13,407 controls )
Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => <searchLink fieldCode="AR" term="%22Jikang+Shi%22">Jikang Shi</searchLink><br /><searchLink fieldCode="AR" term="%22Siyu+Liu%22">Siyu Liu</searchLink><br /><searchLink fieldCode="AR" term="%22Yanbo+Guo%22">Yanbo Guo</searchLink><br /><searchLink fieldCode="AR" term="%22Sainan+Liu%22">Sainan Liu</searchLink><br /><searchLink fieldCode="AR" term="%22Jiayi+Xu%22">Jiayi Xu</searchLink><br /><searchLink fieldCode="AR" term="%22Lingfeng+Pan%22">Lingfeng Pan</searchLink><br /><searchLink fieldCode="AR" term="%22Yueyang+Hu%22">Yueyang Hu</searchLink><br /><searchLink fieldCode="AR" term="%22Yawen+Liu%22">Yawen Liu</searchLink><br /><searchLink fieldCode="AR" term="%22Yi+Cheng%22">Yi Cheng</searchLink> )
Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => BMC Cardiovascular Disorders, Vol 21, Iss 1, Pp 1-11 (2021) )
Array ( [Name] => Publisher [Label] => Publisher Information [Group] => PubInfo [Data] => BMC, 2021. )
Array ( [Name] => DatePubCY [Label] => Publication Year [Group] => Date [Data] => 2021 )
Array ( [Name] => Subset [Label] => Collection [Group] => HoldingsInfo [Data] => LCC:Diseases of the circulatory (Cardiovascular) system )
Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => <searchLink fieldCode="DE" term="%22Hypertension%22">Hypertension</searchLink><br /><searchLink fieldCode="DE" term="%22eNOS%22">eNOS</searchLink><br /><searchLink fieldCode="DE" term="%22rs1799983%22">rs1799983</searchLink><br /><searchLink fieldCode="DE" term="%22Polymorphism%22">Polymorphism</searchLink><br /><searchLink fieldCode="DE" term="%22Meta-analysis%22">Meta-analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Diseases+of+the+circulatory+%28Cardiovascular%29+system%22">Diseases of the circulatory (Cardiovascular) system</searchLink><br /><searchLink fieldCode="DE" term="%22RC666-701%22">RC666-701</searchLink> )
Array ( [Name] => Abstract [Label] => Description [Group] => Ab [Data] => Abstract Background Essential hypertension is a complex disease determined by the interaction of genetic and environmental factors, eNOS is considered to be one of the susceptible genes for hypertension. Our study aimed to evaluate the association between eNOS rs1799983 polymorphism and hypertension, and to provide evidence for the etiology of hypertension. Methods Case–control studies of eNOS rs1799983 polymorphism and hypertension were included by searching PubMed, Embase, Web of Science, Medline, Scopus, WanFang datebase, Vip datebase, and CNKI database according to PRISMA guideline. Eligible data were extracted and pooled, and were analyzed using R software based on five different genetic models. Results A total of 60 eligible articles involving 14,185 cases and 13,407 controls were finally selected. We found significant association between eNOS rs1799983 polymorphism and hypertension under any genetic model (T vs G: OR = 1.44, 95% CI 1.26–1.63; GT vs GG: OR 1.34, 95% CI 1.18–1.52; TT vs GG: OR 1.80, 95% CI 1.41–2.31; GT + TT vs GG: OR 1.42, 95% CI 1.25–1.63; TT vs GG + GT: OR 1.68, 95% CI 1.35–2.08; GT vs GG + TT: OR 1.24, 95% CI 1.11–1.40). Conclusions We found that eNOS rs1799983 polymorphism is associated with the increased risk of hypertension under any genetic model. Moreover, investigations of gene–gene and gene-environment interactions are needed to give more insight into the association between eNOS rs1799983 polymorphism and hypertension. )
Array ( [Name] => TypeDocument [Label] => Document Type [Group] => TypDoc [Data] => article )
Array ( [Name] => Format [Label] => File Description [Group] => SrcInfo [Data] => electronic resource )
Array ( [Name] => Language [Label] => Language [Group] => Lang [Data] => English )
Array ( [Name] => ISSN [Label] => ISSN [Group] => ISSN [Data] => 1471-2261 )
Array ( [Name] => NoteTitleSource [Label] => Relation [Group] => SrcInfo [Data] => https://doaj.org/toc/1471-2261 )
Array ( [Name] => DOI [Label] => DOI [Group] => ID [Data] => 10.1186/s12872-021-02192-2 )
Array ( [Name] => URL [Label] => Access URL [Group] => URL [Data] => <link linkTarget="URL" linkTerm="https://doaj.org/article/0529d6105d0b48ab9aafd1245c96085b" linkWindow="_blank">https://doaj.org/article/0529d6105d0b48ab9aafd1245c96085b</link> )
Array ( [Name] => AN [Label] => Accession Number [Group] => ID [Data] => edsdoj.0529d6105d0b48ab9aafd1245c96085b )
RecordInfo Array ( [BibEntity] => Array ( [Identifiers] => Array ( [0] => Array ( [Type] => doi [Value] => 10.1186/s12872-021-02192-2 ) ) [Languages] => Array ( [0] => Array ( [Text] => English ) ) [PhysicalDescription] => Array ( [Pagination] => Array ( [PageCount] => 11 [StartPage] => 1 ) ) [Subjects] => Array ( [0] => Array ( [SubjectFull] => Hypertension [Type] => general ) [1] => Array ( [SubjectFull] => eNOS [Type] => general ) [2] => Array ( [SubjectFull] => rs1799983 [Type] => general ) [3] => Array ( [SubjectFull] => Polymorphism [Type] => general ) [4] => Array ( [SubjectFull] => Meta-analysis [Type] => general ) [5] => Array ( [SubjectFull] => Diseases of the circulatory (Cardiovascular) system [Type] => general ) [6] => Array ( [SubjectFull] => RC666-701 [Type] => general ) ) [Titles] => Array ( [0] => Array ( [TitleFull] => Association between eNOS rs1799983 polymorphism and hypertension: a meta-analysis involving 14,185 cases and 13,407 controls [Type] => main ) ) ) [BibRelationships] => Array ( [HasContributorRelationships] => Array ( [0] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Jikang Shi ) ) ) [1] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Siyu Liu ) ) ) [2] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Yanbo Guo ) ) ) [3] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Sainan Liu ) ) ) [4] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Jiayi Xu ) ) ) [5] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Lingfeng Pan ) ) ) [6] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Yueyang Hu ) ) ) [7] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Yawen Liu ) ) ) [8] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Yi Cheng ) ) ) ) [IsPartOfRelationships] => Array ( [0] => Array ( [BibEntity] => Array ( [Dates] => Array ( [0] => Array ( [D] => 01 [M] => 08 [Type] => published [Y] => 2021 ) ) [Identifiers] => Array ( [0] => Array ( [Type] => issn-print [Value] => 14712261 ) ) [Numbering] => Array ( [0] => Array ( [Type] => volume [Value] => 21 ) [1] => Array ( [Type] => issue [Value] => 1 ) ) [Titles] => Array ( [0] => Array ( [TitleFull] => BMC Cardiovascular Disorders [Type] => main ) ) ) ) ) ) )
IllustrationInfo