Academic Journal
Supraphysiological Levels of IL-2 in Jak3-Deficient Mice Promote Strong Proliferative Responses of Adoptively Transferred Naive CD8+ T Cells
| العنوان: | Supraphysiological Levels of IL-2 in Jak3-Deficient Mice Promote Strong Proliferative Responses of Adoptively Transferred Naive CD8+ T Cells |
|---|---|
| المؤلفون: | Gil-Woo Lee, Sung-Woo Lee, Juhee Kim, Young-Jun Ju, Hee-Ok Kim, Cheol-Heui Yun, Jae-Ho Cho |
| المصدر: | Frontiers in Immunology, Vol 11 (2021) |
| بيانات النشر: | Frontiers Media S.A., 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Immunologic diseases. Allergy |
| مصطلحات موضوعية: | interleukin-2, naive CD8+ T cells, antigen-independent proliferation, Janus kinase 3, activated CD4+ T cells, CD4+ regulatory T cells, Immunologic diseases. Allergy, RC581-607 |
| الوصف: | The antigen-independent, strong proliferative responses of naive CD8+ T cells have been well demonstrated in a particular strain of mice lacking IL-2 receptors. This type of proliferation is mainly driven by common gamma-chain (γc) cytokines, such as IL-2, IL-7, and IL-15, present at abnormally high levels in these mice. Similarly, in the present study, we showed that mice lacking Janus kinase 3 (Jak3), a tyrosine kinase crucial for γc cytokine signaling, could induce strong proliferation of adoptively transferred naive CD8+ T cells. This proliferation was also independent of antigenic stimulation, but heavily dependent on IL-2, as evidenced by the failure of proliferation of adoptively transferred IL-2 receptor alpha- and beta-chain-deficient naive CD8+ T cells. Consistent with this, Jak3–/– mice showed elevated serum levels of IL-2 compared to wild-type mice, and interestingly, IL-2 production was due to high levels of accumulation of activated CD4+ T cells in Jak3–/– mice along with defective CD4+ T regulatory cells. Collectively, these findings reveal previously unidentified unique immune contexts of Jak3–/– mice that cause robust IL-2-driven T cell expansion and have a clinical implication for designing a treatment strategy for human patients with loss-of-function genetic mutations of Jak3. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1664-3224 |
| Relation: | https://www.frontiersin.org/articles/10.3389/fimmu.2020.616898/full; https://doaj.org/toc/1664-3224 |
| DOI: | 10.3389/fimmu.2020.616898 |
| URL الوصول: | https://doaj.org/article/04ef5b40f53048f4b44f40ec2123c9cb |
| رقم الانضمام: | edsdoj.04ef5b40f53048f4b44f40ec2123c9cb |
| قاعدة البيانات: | Directory of Open Access Journals |
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