Academic Journal
Cross-communication between G and G in a G-protein-coupled receptor heterotetramer guided by a receptor C-terminal domain
| العنوان: | Cross-communication between G and G in a G-protein-coupled receptor heterotetramer guided by a receptor C-terminal domain |
|---|---|
| المؤلفون: | Navarro Brugal, Gemma, Cordomí Montoya, Arnau, Brugarolas, Marc, Moreno, Estefanía, Aguinaga Andrés, David, Pérez-Benito, Laura, Ferré, Sergi, Cortés, Antoni, Casadó, Vicent, Mallol, Josefa, Canela, Enric I., Lluís, Carme, Pardo Carrasco, Leonardo, McCormick, Peter J., Franco, Rafael |
| سنة النشر: | 2018 |
| المجموعة: | Universitat Autònoma de Barcelona: Dipòsit Digital de Documents de la UAB |
| مصطلحات موضوعية: | C-terminal domain, GPCR, Heterotetramer, BRET, Molecular modeling |
| الوصف: | G-protein-coupled receptor (GPCR) heteromeric complexes have distinct properties from homomeric GPCRs, giving rise to new receptor functionalities. Adenosine receptors (AR or AR) can form AR-AR heteromers (A-AHet), and their activation leads to canonical G-protein-dependent (adenylate cyclase mediated) and -independent (β-arrestin mediated) signaling. Adenosine has different affinities for AR and AR, allowing the heteromeric receptor to detect its concentration by integrating the downstream G- and G-dependent signals. cAMP accumulation and β-arrestin recruitment assays have shown that, within the complex, activation of AR impedes signaling via AR. We examined the mechanism by which A-AHet integrates G- and G-dependent signals. AR blockade by AR in the A-AHet is not observed in the absence of AR activation by agonists, in the absence of the C-terminal domain of AR, or in the presence of synthetic peptides that disrupt the heteromer interface of A-AHet, indicating that signaling mediated by AR and AR is controlled by both G and G proteins. We identified a new mechanism of signal transduction that implies a cross-communication between G and G proteins guided by the C-terminal tail of the AR. This mechanism provides the molecular basis for the operation of the A-AHet as an adenosine concentration-sensing device that modulates the signals originating at both AR and AR. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| ردمك: | 978-85-04-25651-2 85-04-25651-0 |
| Relation: | Ministerio de Economía y Competitividad SAF2015-74627-JIN; Ministerio de Economía y Competitividad BFU2015-64405-R; Ministerio de Economía y Competitividad SAF2016-77830-R; BMC biology; Vol. 16 (february 2018); https://ddd.uab.cat/record/253457; urn:10.1186/s12915-018-0491-x; urn:oai:ddd.uab.cat:253457; urn:pmcid:PMC6389107; urn:pmc-uid:6389107; urn:pmid:29486745; urn:oai:pubmedcentral.nih.gov:6389107; urn:oai:egreta.uab.cat:publications/dd33d8fe-877a-4ee9-8642-c8942bb566dc; urn:scopus_id:85042565106 |
| الاتاحة: | https://ddd.uab.cat/record/253457 |
| Rights: | open access ; Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. ; https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.FEFB305D |
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