Academic Journal
Exosomes in the Diagnosis and Treatment of Renal Cell Cancer
| العنوان: | Exosomes in the Diagnosis and Treatment of Renal Cell Cancer |
|---|---|
| المؤلفون: | Stergios Boussios, Perry Devo, Iain C. A. Goodall, Konstantinos Sirlantzis, Aruni Ghose, Sayali D. Shinde, Vasileios Papadopoulos, Elisabet Sanchez, Elie Rassy, Saak V. Ovsepian |
| المصدر: | International Journal of Molecular Sciences, Vol 24, Iss 14356, p 14356 (2023) |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2023 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | renal cell cancer, exosomes, tumor microenvironment, mRNA, miRNA, tumor drug resistance, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Renal cell carcinoma (RCC) is the most prevalent type of kidney cancer originating from renal tubular epithelial cells, with clear cell RCC comprising approximately 80% of cases. The primary treatment modalities for RCC are surgery and targeted therapy, albeit with suboptimal efficacies. Despite progress in RCC research, significant challenges persist, including advanced distant metastasis, delayed diagnosis, and drug resistance. Growing evidence suggests that extracellular vesicles (EVs) play a pivotal role in multiple aspects of RCC, including tumorigenesis, metastasis, immune evasion, and drug response. These membrane-bound vesicles are released into the extracellular environment by nearly all cell types and are capable of transferring various bioactive molecules, including RNA, DNA, proteins, and lipids, aiding intercellular communication. The molecular cargo carried by EVs renders them an attractive resource for biomarker identification, while their multifarious role in the RCC offers opportunities for diagnosis and targeted interventions, including EV-based therapies. As the most versatile type of EVs, exosomes have attracted much attention as nanocarriers of biologicals, with multi-range signaling effects. Despite the growing interest in exosomes, there is currently no widely accepted consensus on their subtypes and properties. The emerging heterogeneity of exosomes presents both methodological challenges and exciting opportunities for diagnostic and clinical interventions. This article reviews the characteristics and functions of exosomes, with a particular reference to the recent advances in their application to the diagnosis and treatment of RCC. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/24/18/14356; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067; https://doaj.org/article/2d2c39f722cb46dc88ce543625abcf65 |
| DOI: | 10.3390/ijms241814356 |
| الاتاحة: | https://doi.org/10.3390/ijms241814356 https://doaj.org/article/2d2c39f722cb46dc88ce543625abcf65 |
| رقم الانضمام: | edsbas.F95B6817 |
| قاعدة البيانات: | BASE |
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