Academic Journal
Increased matrix metalloproteinase-3 serum levels in rheumatic diseases: relationship with synovitis and steroid treatment
| العنوان: | Increased matrix metalloproteinase-3 serum levels in rheumatic diseases: relationship with synovitis and steroid treatment |
|---|---|
| المؤلفون: | Ribbens, Clio, Martin y Porras, M., Franchimont, N., Kaiser, Marie-Joëlle, Jaspar, J. M., Damas, Pierre, Houssiau, F. A., Malaise, Michel |
| المصدر: | Annals of the Rheumatic Diseases, 61 (2), 161-166 (2002) |
| بيانات النشر: | BMJ Group |
| سنة النشر: | 2002 |
| المجموعة: | University of Liège: ORBi (Open Repository and Bibliography) |
| مصطلحات موضوعية: | Biological Markers, Glucocorticoids, Prednisolone, C-Reactive Protein, Matrix Metalloproteinase 3, Human health sciences, Rheumatology, Sciences de la santé humaine, Rhumatologie |
| الوصف: | peer reviewed ; OBJECTIVE: To determine matrix metalloproteinase-3 (MMP-3) serum levels in patients with rheumatic diseases and to study the relation between MMP-3 and C reactive protein (CRP) levels. METHODS: MMP-3 serum levels were determined by enzyme linked immunosorbent assay (ELISA) in (a) patients with active inflammatory rheumatic diseases: rheumatoid arthritis (RA), psoriatic arthritis, polymyalgia rheumatica, acute crystal arthritis, and ankylosing spondylitis; (b) patients with active inflammatory systemic diseases: cutaneo-articular or renal systemic lupus erythematosus (SLE), systemic sclerosis, and vasculitides; (c) patients with non-inflammatory rheumatic diseases: osteoarthritis and fibromyalgia; (d) critically ill patients without rheumatic diseases, representing an acute inflammatory control group; (e) healthy controls. RESULTS: MMP-3 serum levels were significantly increased in patients with active RA, psoriatic arthritis, and polymyalgia rheumatica, whether treated or not by corticosteroids, and in female patients with acute crystal arthritis. MMP-3 serum levels were normal in steroid-free patients with active cutaneo-articular or renal SLE, systemic sclerosis, and vasculitides but were significantly increased in steroid treated patients. MMP-3 levels were normal in fibromyalgia, osteoarthritis, ankylosing spondylitis, and acute inflammatory controls. MMP-3 was significantly correlated with CRP in RA (r=0.5, p=0.0004) but not in any of the other disease groups. CONCLUSIONS: MMP-3 serum levels are increased in inflammatory rheumatic diseases characterised by joint synovitis, such as RA, polymyalgia rheumatica, psoriatic arthritis, and acute crystal arthritis-that is, whether the diseases are acute or chronic, erosive or not. They are normal in SLE, systemic sclerosis, and vasculitides as well as in non-rheumatic inflammatory controls, but are significantly increased by steroids. These data strongly suggest that serum MMP-3 reflects synovial inflammation. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0003-4967 1468-2060 |
| Relation: | urn:issn:0003-4967; urn:issn:1468-2060; https://orbi.uliege.be/handle/2268/72419; info:hdl:2268/72419; info:pmid:11796404 |
| DOI: | 10.1136/ard.61.2.161 |
| الاتاحة: | https://orbi.uliege.be/handle/2268/72419 https://orbi.uliege.be/bitstream/2268/72419/1/Malaise_2002_AnnRheumDis_161-166.pdf https://doi.org/10.1136/ard.61.2.161 |
| Rights: | open access ; http://purl.org/coar/access_right/c_abf2 ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.F7B9BA54 |
| قاعدة البيانات: | BASE |
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