Academic Journal
The association of cognitive impairment with gray matter atrophy and cortical lesion load in clinically isolated syndrome
| العنوان: | The association of cognitive impairment with gray matter atrophy and cortical lesion load in clinically isolated syndrome |
|---|---|
| المؤلفون: | Diker S., Has A.C., Kurne A., Göçmen R., Oğuz K.K., Karabudak R. |
| المصدر: | Multiple Sclerosis and Related Disorders |
| بيانات النشر: | Elsevier B.V. |
| سنة النشر: | 2016 |
| المجموعة: | Bilkent University: Institutional Repository |
| مصطلحات موضوعية: | Clinically isolated syndrome, Cognitive functions, Cortical lesion, Gray matter, Multiple sclerosis, adult, Article, brain atrophy, brain cortex lesion, brain radiography, brain size, cerebellum cortex, clinical article, cognitive defect, controlled study, demyelinating disease, disease association, disease duration, encephalitis, female, gray matter atrophy, hippocampus, human, male, nuclear magnetic resonance imaging, sex ratio, spatial learning, subcortex, verbal memory, white matter lesion |
| الوصف: | Background Multiple sclerosis can impair cognition from the early stages and has been shown to be associated with gray matter damage in addition to white matter pathology. Objectives To investigate the profile of cognitive impairment in clinically isolated syndrome (CIS), and the contribution of cortical inflammation, cortical and deep gray matter atrophy, and white matter lesions to cognitive decline. Methods Thirty patients with clinically isolated syndrome and twenty demographically- matched healthy controls underwent neuropsychologic assessment through the Rao Brief Repeatable Battery, and brain magnetic resonance imaging with double inversion recovery using a 3T scanner. Results Patients with clinically isolated syndrome performed significantly worse than healthy controls on tests that evaluated verbal memory, visuospatial learning and memory, and verbal fluency. Significant deep gray matter atrophy was found in the patients but cortical volume was not lower than the controls. Visual memory tests correlated with the volume of the hippocampus, cerebral white matter and deep gray matter structures and with cerebellar cortical atrophy. Cortical or white matter lesion load did not affect cognitive test results. Conclusion In our patients with CIS, it was shown that cognitive impairment was mainly related to cerebral white matter, cerebellar cortical and deep gray matter atrophy, but not with cortical inflammation, at least in the early stage of disease. © 2016 Elsevier B.V. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 22110348 |
| Relation: | http://dx.doi.org/10.1016/j.msard.2016.08.008; http://hdl.handle.net/11693/36805 |
| DOI: | 10.1016/j.msard.2016.08.008 |
| الاتاحة: | http://hdl.handle.net/11693/36805 https://doi.org/10.1016/j.msard.2016.08.008 |
| رقم الانضمام: | edsbas.EFD4751A |
| قاعدة البيانات: | BASE |
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