Academic Journal
Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells
| العنوان: | Indoleamine 2,3-dioxygenase is a signaling protein in long-term tolerance by dendritic cells |
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| المؤلفون: | PALLOTTA, MARIA TERESA, ORABONA, Ciriana, VOLPI, CLAUDIA, VACCA, Carmine, BELLADONNA, Maria Laura, BIANCHI, Roberta, SERVILLO, Giuseppe, BRUNACCI, CINZIA, CALVITTI, Mario, S. Bicciato, E. M. Mazza, L. Boon, F. Grassi, FIORETTI, Maria Cristina, FALLARINO, Francesca, PUCCETTI, Paolo, GROHMANN, Ursula |
| المساهمون: | Pallotta, MARIA TERESA, Orabona, Ciriana, Volpi, Claudia, Vacca, Carmine, Belladonna, Maria Laura, Bianchi, Roberta, Servillo, Giuseppe, Brunacci, Cinzia, Calvitti, Mario, S., Bicciato, E. M., Mazza, L., Boon, F., Grassi, Fioretti, Maria Cristina, Fallarino, Francesca, Puccetti, Paolo, Grohmann, Ursula |
| سنة النشر: | 2011 |
| المجموعة: | IRIS Università degli Studi di Perugia |
| مصطلحات موضوعية: | IDO, indoleamine 2, 3-dioxygenase, tryptophan catabolism, dendritic cell, immune regulation |
| الوصف: | Regulation of tryptophan metabolism by indoleamine 2,3-dioxygenase (IDO) in dendritic cells (DCs) is a highly versatile modulator of immunity. In inflammation, interferon-γ is the main inducer of IDO for the prevention of hyperinflammatory responses, yet IDO is also responsible for self-tolerance effects in the longer term. Here we show that treatment of mouse plasmacytoid DCs (pDCs) with transforming growth factor-β (TGF-β) conferred regulatory effects on IDO that were mechanistically separable from its enzymic activity. We found that IDO was involved in intracellular signaling events responsible for the self-amplification and maintenance of a stably regulatory phenotype in pDCs. Thus, IDO has a tonic, nonenzymic function that contributes to TGF-β-driven tolerance in noninflammatory contexts. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/21804557; info:eu-repo/semantics/altIdentifier/wos/WOS:000294461200011; volume:12; issue:9; firstpage:870; lastpage:878; numberofpages:9; journal:NATURE IMMUNOLOGY; http://hdl.handle.net/11391/409095; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-80052020183; https://www.nature.com/articles/ni.2077 |
| DOI: | 10.1038/ni.2077 |
| الاتاحة: | http://hdl.handle.net/11391/409095 https://doi.org/10.1038/ni.2077 https://www.nature.com/articles/ni.2077 |
| رقم الانضمام: | edsbas.EFB18B8E |
| قاعدة البيانات: | BASE |
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