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Toward individualized medicine in stroke-The TiMeS project: Protocol of longitudinal, multi-modal, multi-domain study in stroke.

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العنوان: Toward individualized medicine in stroke-The TiMeS project: Protocol of longitudinal, multi-modal, multi-domain study in stroke.
المؤلفون: Fleury, L., Koch, P.J., Wessel, M.J., Bonvin, C., San Millan, D., Constantin, C., Vuadens, P., Adolphsen, J., Cadic Melchior, A., Brügger, J., Beanato, E., Ceroni, M., Menoud, P., De Leon Rodriguez, D., Zufferey, V., Meyer, N.H., Egger, P., Harquel, S., Popa, T., Raffin, E., Girard, G., Thiran, J.P., Vaney, C., Alvarez, V., Turlan, J.L., Mühl, A., Léger, B., Morishita, T., Micera, S., Blanke, O., Van De Ville, D., Hummel, F.C.
المصدر: Frontiers in neurology, vol. 13, pp. 939640
سنة النشر: 2022
المجموعة: Université de Lausanne (UNIL): Serval - Serveur académique lausannois
مصطلحات موضوعية: biomarkers, electroencephalography, neuroimaging, neurorehabilitation, precision medicine, recovery, stroke, transcranial magnetic stimulation
الوصف: Despite recent improvements, complete motor recovery occurs in <15% of stroke patients. To improve the therapeutic outcomes, there is a strong need to tailor treatments to each individual patient. However, there is a lack of knowledge concerning the precise neuronal mechanisms underlying the degree and course of motor recovery and its individual differences, especially in the view of brain network properties despite the fact that it became more and more clear that stroke is a network disorder. The TiMeS project is a longitudinal exploratory study aiming at characterizing stroke phenotypes of a large, representative stroke cohort through an extensive, multi-modal and multi-domain evaluation. The ultimate goal of the study is to identify prognostic biomarkers allowing to predict the individual degree and course of motor recovery and its underlying neuronal mechanisms paving the way for novel interventions and treatment stratification for the individual patients. A total of up to 100 patients will be assessed at 4 timepoints over the first year after the stroke: during the first (T1) and third (T2) week, then three (T3) and twelve (T4) months after stroke onset. To assess underlying mechanisms of recovery with a focus on network analyses and brain connectivity, we will apply synergistic state-of-the-art systems neuroscience methods including functional, diffusion, and structural magnetic resonance imaging (MRI), and electrophysiological evaluation based on transcranial magnetic stimulation (TMS) coupled with electroencephalography (EEG) and electromyography (EMG). In addition, an extensive, multi-domain neuropsychological evaluation will be performed at each timepoint, covering all sensorimotor and cognitive domains. This project will significantly add to the understanding of underlying mechanisms of motor recovery with a strong focus on the interactions between the motor and other cognitive domains and multimodal network analyses. The population-based, multi-dimensional dataset will serve as a basis to ...
نوع الوثيقة: article in journal/newspaper
review
وصف الملف: application/pdf
اللغة: English
Relation: info:eu-repo/semantics/altIdentifier/pmid/36226086; info:eu-repo/semantics/altIdentifier/pissn/1664-2295; info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_DFF9F8458FD08; https://serval.unil.ch/notice/serval:BIB_DFF9F8458FD0; https://serval.unil.ch/resource/serval:BIB_DFF9F8458FD0.P001/REF.pdf
DOI: 10.3389/fneur.2022.939640
الاتاحة: https://serval.unil.ch/notice/serval:BIB_DFF9F8458FD0
https://doi.org/10.3389/fneur.2022.939640
https://serval.unil.ch/resource/serval:BIB_DFF9F8458FD0.P001/REF.pdf
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_DFF9F8458FD08
Rights: info:eu-repo/semantics/openAccess ; CC BY 4.0 ; https://creativecommons.org/licenses/by/4.0/
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