Academic Journal
Measurement of serum parathyroid hormone during the early postoperative period as a predictor of clinical hypocalcaemia ; Определение уровня паратиреоидного гормона в раннем послеоперационном периоде как прогностического показателя клинической гипокальциемии ; Визначення рівня паратиреоїдного гормону в ранньому післяопераційному періоді як прогностичного чинника клінічної гіпокальціємії
| العنوان: | Measurement of serum parathyroid hormone during the early postoperative period as a predictor of clinical hypocalcaemia ; Определение уровня паратиреоидного гормона в раннем послеоперационном периоде как прогностического показателя клинической гипокальциемии ; Визначення рівня паратиреоїдного гормону в ранньому післяопераційному періоді як прогностичного чинника клінічної гіпокальціємії |
|---|---|
| المؤلفون: | Нечай, О. П., Товкай, О. А., Черенько, С. М. |
| المصدر: | Clinical Endocrinology and Endocrine Surgery; No. 4(60) (2017); 30-36 ; Clinical Endocrinology and Endocrine Surgery; № 4(60) (2017); 30-36 ; 2519-2582 ; 1818-1384 |
| بيانات النشر: | УНПЦЕХ, ТЕОіТ МОЗ України (URPCES, TEO&T of the Ministry of Health of Ukraine) |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | thyroidectomy, parathyroid hormone, postoperative hypocalcaemia, prediction, тиреоидэктомия, паратиреоидный гормон, послеоперационная гипокальциемия, прогнозирование, тиреоїдектомія, паратгормон, післяопераційна гіпокальціємія, передбачення |
| الوصف: | Aim – to assess the risk of postoperative hypoparathyroidism and hypocalcaemia depending on the parathyroid hormone (PTH) blood levels in the early postoperative period in patients underwent thyroid surgery of different volume. Materials and methods. The results of serum PTH and ionized calcium (Ca++) levels in 305 patients operated on thyroid gland were analyzed. They included: thyroidectomy for Graves' disease (76 patients), hemithyroidectomy for nodular goiter (12 patients), hemithyroidectomy with lymphadenectomy for suspected cancer (19 patients), thyroidectomy for multinodular goiter (24 patients), thyroidectomy with lymphadenectomy for multinodular goiter, suspected or proven thyroid cancer (174 patients). According to the degree of clinical manifestations of hypocalcaemia, patients were divided into 4 groups: 1 – absence of obvious clinical manifestations, 184 (60.33%), 2 – mild form, 62 (20.33%), 3 – medium severity, 36 (11.8%), 4 – severe form, 23 (7.54%). Results and Discussion. The increase in the degree of clinical manifestations of hypocalcaemia correlated with the decrease in mean level of PTH and Ca++ in serum. Thus, patients of group 1 (184) had an average PTH level of 25.86 pg/ml (range: 14.23 – 51.39 pg/ml), and the mean level of Ca++ blood was 1.16 mmol/l (1.0 – 1.26 mmol/l). Patients of 2 group demonstrated the average level of PTH 12.92 pg/ml (8.12 – 16.36 pg/ml), and the average level of Ca++ 0.98 mmol/l (0.92 – 1.05 mmol/l). Patients of 3 group had average PTH levels of 7.67 pg/ml (4.54 – 11.19 pg/ml), Ca++ 0.84 mmol/l (0.78 – 0.97 mmol/l); and patients with severe form – PTH 3.42 pg/ml (0.2 – 6.38 pg/ml), Ca++ 0.68 mmol/l (0.62 – 0.83 mmol/l). The mean blood levels of PTH and Са++ decrease depending on the degree of clinical manifestations of hypocalcaemia. With an increase in the volume of surgical intervention, the number of cases of iatrogenic hypoparathyroidism and hypocalcaemia increased: hemithyroidectomy with lymphadenectomy resulted with hypocalcaemia in 4 patients (21.05%), ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | Ukrainian |
| Relation: | http://jcees.endocenter.kiev.ua/article/view/118738/113686; http://jcees.endocenter.kiev.ua/article/view/118738 |
| DOI: | 10.24026/1818-1384.4(60).2017.118738 |
| الاتاحة: | http://jcees.endocenter.kiev.ua/article/view/118738 https://doi.org/10.24026/1818-1384.4(60).2017.118738 |
| Rights: | Авторське право (c) 2017 Клінічна ендокринологія та ендокринна хірургія ; https://creativecommons.org/licenses/by-nc/4.0 |
| رقم الانضمام: | edsbas.EC33B62D |
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Materials and methods. The results of serum PTH and ionized calcium (Ca++) levels in 305 patients operated on thyroid gland were analyzed. They included: thyroidectomy for Graves' disease (76 patients), hemithyroidectomy for nodular goiter (12 patients), hemithyroidectomy with lymphadenectomy for suspected cancer (19 patients), thyroidectomy for multinodular goiter (24 patients), thyroidectomy with lymphadenectomy for multinodular goiter, suspected or proven thyroid cancer (174 patients). According to the degree of clinical manifestations of hypocalcaemia, patients were divided into 4 groups: 1 – absence of obvious clinical manifestations, 184 (60.33%), 2 – mild form, 62 (20.33%), 3 – medium severity, 36 (11.8%), 4 – severe form, 23 (7.54%). Results and Discussion. The increase in the degree of clinical manifestations of hypocalcaemia correlated with the decrease in mean level of PTH and Ca++ in serum. 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