التفاصيل البيبلوغرافية
| العنوان: |
Involvement of 14-3-3 Proteins in Regulating Tumor Progression of Hepatocellular Carcinoma |
| المؤلفون: |
Yi-Ju Wu, Yee-Jee Jan, Bor-Sheng Ko, Shu-Man Liang, Jun-Yang Liou |
| المصدر: |
Cancers; Volume 7; Issue 2; Pages: 1022-1036 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2015 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
14-3-3, apoptosis, epithelial-mesenchymal transition, hepatocellular carcinoma, migration, proliferation |
| الوصف: |
There are seven mammalian isoforms of the 14-3-3 protein, which regulate multiple cellular functions via interactions with phosphorylated partners. Increased expression of 14-3-3 proteins contributes to tumor progression of various malignancies. Several isoforms of 14-3-3 are overexpressed and associate with higher metastatic risks and poorer survival rates of hepatocellular carcinoma (HCC). 14-3-3β and 14-3-3ζ regulate HCC cell proliferation, tumor growth and chemosensitivity via modulating mitogen-activated protein kinase (MAPK), c-Jun N-terminal kinase (JNK) and p38 signal pathways. Moreover, 14-3-3ε suppresses E-cadherin and induces focal adhesion kinase (FAK) expression, thereby enhancing epithelial-mesenchymal transition (EMT) and HCC cell migration. 14-3-3ζ forms complexes with αB-crystallin, which induces EMT and is the cause of sorafenib resistance in HCC. Finally, a recent study has indicated that 14-3-3σ induces heat shock protein 70 (HSP70) expression, which increases HCC cell migration. These results suggest that selective 14-3-3 isoforms contribute to cell proliferation, EMT and cell migration of HCC by regulating distinct targets and signal pathways. Targeting 14-3-3 proteins together with specific downstream effectors therefore has potential to be therapeutic and prognostic factors of HCC. In this article, we will overview 14-3-3's regulation of its downstream factors and contributions to HCC EMT, cell migration and proliferation. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
https://dx.doi.org/10.3390/cancers7020822 |
| DOI: |
10.3390/cancers7020822 |
| الاتاحة: |
https://doi.org/10.3390/cancers7020822 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.E9D5EBB0 |
| قاعدة البيانات: |
BASE |