Academic Journal
Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysiology of Chronic Diseases
| العنوان: | Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysiology of Chronic Diseases |
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| المؤلفون: | Sharifi-Rad, M, Anil Kumar, NV, Zucca, P, Varoni, EM, Dini, L, Panzarini, E, Rajkovic, J, Tsouh Fokou, PV, Azzini, E, Peluso, I, Prakash Mishra, A, Nigam, M, El Rayess, Y, Beyrouthy, ME, Polito, L, Iriti, M, Martins, N, Martorell, M, Docea, AO, Setzer, WN, Calina, D, Cho, WC, Sharifi-Rad, J |
| المساهمون: | Instituto de Investigação e Inovação em Saúde |
| بيانات النشر: | Frontiers Media |
| سنة النشر: | 2020 |
| المجموعة: | Repositório Aberto da Universidade do Porto |
| مصطلحات موضوعية: | aging, antioxidant defense, cancer, cardiovascular diseases, natural antioxidants, neurological disorders, oxidative stress, reactive oxygen species |
| الوصف: | Oxidative stress plays an essential role in the pathogenesis of chronic diseases such as cardiovascular diseases, diabetes, neurodegenerative diseases, and cancer. Long term exposure to increased levels of pro-oxidant factors can cause structural defects at a mitochondrial DNA level, as well as functional alteration of several enzymes and cellular structures leading to aberrations in gene expression. The modern lifestyle associated with processed food, exposure to a wide range of chemicals and lack of exercise plays an important role in oxidative stress induction. However, the use of medicinal plants with antioxidant properties has been exploited for their ability to treat or prevent several human pathologies in which oxidative stress seems to be one of the causes. In this review we discuss the diseases in which oxidative stress is one of the triggers and the plant-derived antioxidant compounds with their mechanisms of antioxidant defenses that can help in the prevention of these diseases. Finally, both the beneficial and detrimental effects of antioxidant molecules that are used to reduce oxidative stress in several human conditions are discussed. ; This work was supported by the CONICYT PIA/APOYO CCTE AFB170007. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1664-042X |
| Relation: | Frontiers in Physiology, vol.11:694; https://www.frontiersin.org/articles/10.3389/fphys.2020.00694/full; https://hdl.handle.net/10216/143526 |
| DOI: | 10.3389/fphys.2020.00694 |
| الاتاحة: | https://hdl.handle.net/10216/143526 https://doi.org/10.3389/fphys.2020.00694 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.DD765CFD |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 1664042X |
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| DOI: | 10.3389/fphys.2020.00694 |