Academic Journal
Oxidative Stress and the Nrf2/PPARγ Axis in the Endometrium: Insights into Female Fertility
| العنوان: | Oxidative Stress and the Nrf2/PPARγ Axis in the Endometrium: Insights into Female Fertility |
|---|---|
| المؤلفون: | Peter Artimovič, Zuzana Badovská, Silvia Toporcerová, Ivana Špaková, Lukáš Smolko, Gabriela Sabolová, Eva Kriváková, Miroslava Rabajdová |
| المصدر: | Cells, Vol 13, Iss 13, p 1081 (2024) |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2024 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Nrf2, PPARγ, oxidative stress, endometrium, fertility, cellular signaling, Cytology, QH573-671 |
| الوصف: | Successful pregnancy depends on precise molecular regulation of uterine physiology, especially during the menstrual cycle. Deregulated oxidative stress (OS), often influenced by inflammatory changes but also by environmental factors, represents a constant threat to this delicate balance. Oxidative stress induces a reciprocally regulated nuclear factor erythroid 2-related factor 2/peroxisome proliferator-activated receptor-gamma (Nrf2/PPARγ) pathway. However, increased PPARγ activity appears to be a double-edged sword in endometrial physiology. Activated PPARγ attenuates inflammation and attenuates OS to restore redox homeostasis. However, it also interferes with physiological processes during the menstrual cycle, such as hormonal signaling and angiogenesis. This review provides an elucidation of the molecular mechanisms that support the interplay between PPARγ and OS. Additionally, it offers fresh perspectives on the Nrf2/PPARγ pathway concerning endometrial receptivity and its potential implications for infertility. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2073-4409 |
| Relation: | https://www.mdpi.com/2073-4409/13/13/1081; https://doaj.org/toc/2073-4409; https://doaj.org/article/3049c079f7564aba862807bcecd06bf7 |
| DOI: | 10.3390/cells13131081 |
| الاتاحة: | https://doi.org/10.3390/cells13131081 https://doaj.org/article/3049c079f7564aba862807bcecd06bf7 |
| رقم الانضمام: | edsbas.DAF15E0F |
| قاعدة البيانات: | BASE |
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