Academic Journal
Anatolan sage Salva frutcosa nhbts cytosolc glutathone-s-transferase actvty and colon cancer cell prolferaton
| العنوان: | Anatolan sage Salva frutcosa nhbts cytosolc glutathone-s-transferase actvty and colon cancer cell prolferaton |
|---|---|
| المؤلفون: | Altay, Ahmet, Suloglu, Aysun Kilic, Celep, Gulcin Sagdicoglu, Selmanoglu, Guldeniz, Bozoglu, Faruk |
| بيانات النشر: | Springer |
| سنة النشر: | 2019 |
| المجموعة: | Doğuş University Institutional Repository (DSpace@Dogus) / Doğuş Üniversitesi Akademik Arşiv Sistemi |
| مصطلحات موضوعية: | Salvia fruticosa, Antioxidant activity, Cytotoxicity, Enzyme inhibition, Colon cancer, Antioxidant Properties, Phenolic Composition, Fruticosa Miller, Rosmarinic Acid, Gc-Ms, Plants, Extracts, Dna, Proliferation |
| الوصف: | Colorectal cancer is one of the leading causes of death worldwide, and healthy diet is critical in preventing it. This study intends to investigate phenolic profile, antioxidant, and anti-proliferative activity as well as Glutathione S-transferase (GST) inhibition activity of water extract of Salvia fruticosa Mill. (SF.) HPLC analysis revealed that the main bioactive ingredients of SF were rosmarinic and caffeic acid. Total phenolic and flavonoid contents were 425.1mg GAE/g extract and 94.7mg CE/g extract, respectively. SF exhibited high antioxidant activity through DPPH and ABTS assays. The extract exhibited time and dose-dependent anti-proliferative activity on colorectal adenocarcinoma cell lines (Caco-2 and HT-29). The extract also inhibited GST activity in a mixed-type manner, with an IC50 value of 6.8 mu g/mL. To conclude, the results suggest that SF may be considered as a medicinal plant which can be used in theprevention and treatment of colon cancer, besides chemotherapy drugs. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| ردمك: | 978-0-00-466353-1 0-00-466353-5 |
| تدمد: | 2193-4126 2193-4134 |
| Relation: | Journal Of Food Measurement And Characterization; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://doi.org/10.1007/s11694-019-00055-1; https://hdl.handle.net/11376/3962; 13; 1390; 1399; WOS:000466353500051; 2-s2.0-85061630356; Q3; Q2 |
| DOI: | 10.1007/s11694-019-00055-1 |
| الاتاحة: | https://doi.org/10.1007/s11694-019-00055-1 https://hdl.handle.net/11376/3962 |
| Rights: | info:eu-repo/semantics/closedAccess |
| رقم الانضمام: | edsbas.DAA08726 |
| قاعدة البيانات: | BASE |
| ردمك: | 9780004663531 0004663535 |
|---|---|
| تدمد: | 21934126 21934134 |
| DOI: | 10.1007/s11694-019-00055-1 |