التفاصيل البيبلوغرافية
| العنوان: |
Simple and Rapid Method for Wogonin Preparation and Its Biotransformation |
| المؤلفون: |
Tomasz Tronina, Monika Mrozowska, Agnieszka Bartmańska, Jarosław Popłoński, Sandra Sordon, Ewa Huszcza |
| المصدر: |
International Journal of Molecular Sciences; Volume 22; Issue 16; Pages: 8973 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2021 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
wogonin, baicalein, isolation, biotransformation, Scutellaria baicalensis, Radix Scutellariae, baikal skullcap |
| جغرافية الموضوع: |
agris |
| الوصف: |
Wogonin is one of the most active flavonoids from Scutellaria baicalensis Georgi (baikal skullcap), widely used in traditional Chinese medicine. It exhibits a broad spectrum of health-promoting and therapeutic activities. Together with baicalein, it is considered to be the one of main active ingredients of Chinese medicines for the management of COVID-19. However, therapeutic use of wogonin may be limited due to low market availability connected with its low content in baikal skullcap and lack of efficient preparative methods for obtaining this compound. Although the amount of wogonin in skullcap root often does not exceed 0.5%, this material is rich in wogonin glucuronide, which may be used as a substrate for wogonin production. In the present study, a rapid, simple, cheap and effective method of wogonin and baicalein preparation, which provides gram quantities of both flavonoids, is proposed. The obtained wogonin was used as a substrate for biotransformation. Thirty-six microorganisms were tested in screening studies. The most efficient were used in enlarged scale transformations to determine metabolism of this xenobiotic. The major phase I metabolism product was 4′-hydroxywogonin—a rare flavonoid which exhibits anticancer activity—whereas phase II metabolism products were glucosides of wogonin. The present studies complement and extend the knowledge on the effect of substitution of A- and B-ring on the regioselective glycosylation of flavonoids catalyzed by microorganisms. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Molecular Role of Xenobiotics; https://dx.doi.org/10.3390/ijms22168973 |
| DOI: |
10.3390/ijms22168973 |
| الاتاحة: |
https://doi.org/10.3390/ijms22168973 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.D9F25B1A |
| قاعدة البيانات: |
BASE |