Academic Journal
546 Using Contingency Management to Understand the Cardiovascular, Immune and Psychosocial Benefits of Reduced Cocaine Use: A Protocol for a Randomized Controlled Trial
| العنوان: | 546 Using Contingency Management to Understand the Cardiovascular, Immune and Psychosocial Benefits of Reduced Cocaine Use: A Protocol for a Randomized Controlled Trial |
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| المؤلفون: | Sean Regnier, Jennifer R. Havens, Thomas P. Shellenberg, David H. Cox, Thomas S. Baker, Joshua A. Lile, Craig R. Rush, Reuben Adatorwovor, Lon R. Hays, Danielle M. Anderson, Mary B. Fisher, Suzanne C. Segerstrom, Joy M. Schmitz, William W. Stoops |
| المصدر: | Journal of Clinical and Translational Science, Vol 8, Pp 163-163 (2024) |
| بيانات النشر: | Cambridge University Press |
| سنة النشر: | 2024 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Medicine |
| الوصف: | OBJECTIVES/GOALS: Contingency management (CM) procedures yield measurable reductions in cocaine use. This poster describes a trial aimed at using CM as a vehicle to show the biopsychosocial health benefits of reduced use, rather than total abstinence, the currently accepted metric for treatment efficacy. METHODS/STUDY POPULATION: In this 12-week, randomized controlled trial, CM was used to reduce cocaine use and evaluate associated improvements in cardiovascular, immune, and psychosocial well-being. Adults aged 18 and older who sought treatment for cocaine use (N=127) were randomized into three groups in a 1:1:1 ratio: High Value ($55) or Low Value ($13) CM incentives for cocaine-negative urine samples or a non-contingent control group. They completed outpatient sessions three days per week across the 12-week intervention period, totaling 36 clinic visits and four post-treatment follow-up visits. During each visit, participants provided observed urine samples and completed several assays of biopsychosocial health. RESULTS/ANTICIPATED RESULTS: Preliminary findings from generalized linear mixed effect modeling demonstrate the feasibility of the CM platform. Abstinence rates from cocaine use were significantly greater in the High Value group (47% negative; OR = 2.80; p = 0.01) relative to the Low Value (23% negative) and Control groups (24% negative;). In the planned primary analysis, the level of cocaine use reduction based on cocaine-negative urine samples will serve as the primary predictor of cardiovascular (e.g., endothelin-1 levels), immune (e.g., IL-10 levels) and psychosocial (e.g., Addiction Severity Index) outcomes using results from the fitted models. DISCUSSION/SIGNIFICANCE: This research will advance the field by prospectively and comprehensively demonstrating the beneficial effects of reduced cocaine use. These outcomes can, in turn, support the adoption of reduced cocaine use as a viable alternative endpoint in cocaine treatment trials. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2059-8661 |
| Relation: | https://www.cambridge.org/core/product/identifier/S2059866124004667/type/journal_article; https://doaj.org/toc/2059-8661; https://doaj.org/article/d070f9320c374f3ab0eb8c649c784cf1 |
| DOI: | 10.1017/cts.2024.466 |
| الاتاحة: | https://doi.org/10.1017/cts.2024.466 https://doaj.org/article/d070f9320c374f3ab0eb8c649c784cf1 |
| رقم الانضمام: | edsbas.D7D462D7 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20598661 |
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| DOI: | 10.1017/cts.2024.466 |