Academic Journal
Clonal hematopoiesis in patients with stem cell mobilization failure:a nested case-control study
| العنوان: | Clonal hematopoiesis in patients with stem cell mobilization failure:a nested case-control study |
|---|---|
| المؤلفون: | Hazenberg, Carin L.E., de Graaf, Aniek O., Mulder, René, Bungener, Laura B., van Bergen, Maaike G.J.M., Mulder, André B., Choi, Goda, Schuringa, Jan Jacob, de Groot, Marco R., Vellenga, Edo, Jansen, Joop H., Huls, Gerwin, van Zeventer, Isabelle A. |
| المصدر: | Hazenberg , C L E , de Graaf , A O , Mulder , R , Bungener , L B , van Bergen , M G J M , Mulder , A B , Choi , G , Schuringa , J J , de Groot , M R , Vellenga , E , Jansen , J H , Huls , G & van Zeventer , I A 2023 , ' Clonal hematopoiesis in patients with stem cell mobilization failure : a nested case-control study ' , Blood Advances , vol. 7 , no. 7 , pp. 1269-1278 . https://doi.org/10.1182/bloodadvances.2022007497 |
| سنة النشر: | 2023 |
| المجموعة: | University of Groningen research database |
| الوصف: | Inadequate mobilization of peripheral blood progenitor cells (PBPCs) is a limiting factor to proceeding with autologous hematopoietic cell transplantation (auto-HCT). To assess the impact of clonal hematopoiesis (CH) on mobilization failure of PBPC for auto-HCT, we investigated the characteristics of poor mobilizers (with a total PBPC collection <2 × 10 6 CD34 + cells per kg) in a consecutive single-center cohort of 776 patients. Targeted error-corrected next-generation sequencing of 28 genes was performed in a nested case-control cohort of 90 poor mobilizers and 89 matched controls. CH was detected in 48 out of 179 patients (27%), with most patients carrying a single mutation. The presence of CH (detected at variant allele frequency [VAF] ≥ 1%) did not associate with poor mobilization potential (31% vs 22% in controls, odds ratio, 1.55; 95% confidence interval, 0.76-3.23; P = .238). PPM1D mutations were detected more often in poor mobilizers (P = .005). In addition, TP53 mutations in this cohort were detected exclusively in patients with poor mobilization potential (P = .06). The incidence of therapy-related myeloid neoplasms (t-MN) was higher among patients with mobilization failure (P = .014). Although poor mobilizers experienced worse overall survival (P = .019), this was not affected by the presence of CH. We conclude that CH at low VAF (1%-10%) is common at the time of stem cell mobilization. TP53 mutations and PPM1D mutations are associated with poor mobilization potential and their role in subsequent development of t-MN in these individuals should be established. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| DOI: | 10.1182/bloodadvances.2022007497 |
| الاتاحة: | https://hdl.handle.net/11370/51f10be8-c0e8-4303-ba97-94d4f2ae12a7 https://research.rug.nl/en/publications/51f10be8-c0e8-4303-ba97-94d4f2ae12a7 https://doi.org/10.1182/bloodadvances.2022007497 https://pure.rug.nl/ws/files/750490299/blooda_adv-2022-007497-main.pdf |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.D77A3B1A |
| قاعدة البيانات: | BASE |
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