التفاصيل البيبلوغرافية
| العنوان: |
Inhibition of nicotinamide phosphoribosyltransferase reduces neutrophil-mediated injury in myocardial infarction |
| المؤلفون: |
Montecucco, Fabrizio, Bauer, Inga, Braunersreuther, Vincent, Bruzzone, Santina, Akhmedov, Alexander, Lüscher, Thomas F, Speer, Timo, Poggi, Alessandro, Mannino, Elena, Pelli, Graziano, Galan, Katia, Bertolotto, Maria, Lenglet, Sébastien, Garuti, Anna, Montessuit, Christophe Albert, Lerch, René, Pellieux, Corinne, Vuilleumier, Nicolas, Dallegri, Franco, Mage, Jacqueline, Sebastian, Carlos, Mostoslavsky, Raul, Gayet-Ageron, Angèle, Patrone, Franco, Mach, François, Nencioni, Alessio |
| المصدر: |
ISSN: 1523-0864 ; Antioxidants & redox signaling, vol. 18, no. 6 (2013) p. 630-641. |
| سنة النشر: |
2013 |
| المجموعة: |
Université de Genève: Archive ouverte UNIGE |
| مصطلحات موضوعية: |
info:eu-repo/classification/ddc/576, info:eu-repo/classification/ddc/613, info:eu-repo/classification/ddc/614.1, info:eu-repo/classification/ddc/616, Acrylamides/administration & dosage, Animals, Chemokine CXCL2/metabolism, Humans, Male, Mice, Myocardial Infarction/drug therapy/enzymology/pathology, Myocardial Reperfusion Injury/drug therapy/pathology, NAD/biosynthesis, Neutrophil Infiltration/drug effects, Nicotinamide Phosphoribosyltransferase/antagonists & inhibitors/metabolism, Oxidative Stress/drug effects, Piperidines/administration & dosage, Reactive Oxygen Species/metabolism, Signal Transduction |
| الوصف: |
Nicotinamide phosphoribosyltransferase (Nampt) is a key enzyme for nicotinamide adenine dinucleotide (NAD(+)) biosynthesis, and recent evidence indicates its role in inflammatory processes. Here, we investigated the potential effects of pharmacological Nampt inhibition with FK866 in a mouse myocardial ischemia/reperfusion model. In vivo and ex vivo mouse myocardial ischemia/reperfusion procedures were performed. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| Relation: |
info:eu-repo/semantics/altIdentifier/pmid/22452634; https://archive-ouverte.unige.ch/unige:42482; unige:42482 |
| الاتاحة: |
https://archive-ouverte.unige.ch/unige:42482 |
| Rights: |
info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edsbas.D6BA67E4 |
| قاعدة البيانات: |
BASE |