Academic Journal
Understanding adjuvant endocrine therapy persistence in breast Cancer survivors
| العنوان: | Understanding adjuvant endocrine therapy persistence in breast Cancer survivors |
|---|---|
| المؤلفون: | Lambert, Leah K, Balneaves, Lynda G, Howard, A. Fuchsia, Chia, Stephen K, Gotay, Carolyn C |
| سنة النشر: | 2018 |
| المجموعة: | MSpace at the University of Manitoba |
| الوصف: | Background Adjuvant endocrine therapy (AET) significantly decreases the risk of breast cancer recurrence and mortality. Notwithstanding the demonstrated efficacy of AET, 31–73% of breast cancer survivors do not persist with AET. The purpose of this study was to explore breast cancer survivors’ experiences and perspectives of persisting with AET and to identify the psychosocial and healthcare system factors that influence AET persistence. Methods Informed by interpretive descriptive methodology and relational autonomy theory, individual interviews were conducted with 22 women diagnosed with early-stage breast cancer who had been prescribed AET. These participants also completed a demographic form and a survey that assessed their perceived risk of recurrence. Interviews were analysed using inductive thematic and constant comparative analysis to iteratively compare data and develop conceptualizations of the relationships among data. Descriptive statistics were used to summarize the quantitative data. Results The personal, social, and structural factors found to influence AET persistence included AET side effects, perception of breast cancer recurrence risk, medication and necessity beliefs, social support, the patient-provider relationship, and the continuity and frequency of follow-up care. For most women, over time, the decision-making process around AET persistence became a balancing act between quality of life and quantity of life. The interplay between the personal, social, and structural factors was complex and the weight women placed on some factors over others influenced their AET persistence or non-persistence. Conclusion Expanding our understanding of the factors affecting breast cancer survivors’ AET persistence from their perspective is the first step in developing efficacious, patient-centered interventions aimed at improving AET persistence. In order to improve AET persistence, enhanced symptom management is required, as well as the development of supportive care strategies that acknowledge ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | BMC Cancer. 2018 Jul 11;18(1):732; https://doi.org/10.1186/s12885-018-4644-7; http://hdl.handle.net/1993/33189 |
| DOI: | 10.1186/s12885-018-4644-7 |
| الاتاحة: | http://hdl.handle.net/1993/33189 https://doi.org/10.1186/s12885-018-4644-7 |
| Rights: | open access ; The Author(s). |
| رقم الانضمام: | edsbas.D689DF84 |
| قاعدة البيانات: | BASE |
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