Academic Journal
Effects of KEAP1 silencing on the regulation of NRF2 activity in neuroendocrine lung tumors
| العنوان: | Effects of KEAP1 silencing on the regulation of NRF2 activity in neuroendocrine lung tumors |
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| المؤلفون: | Sparaneo A., Fabrizio F. P., la Torre A., Graziano P., Di Maio M., Fontana A., Bisceglia M., Rossi A., Pizzolitto S., De Maglio G., Tancredi A., Grimaldi F., Balsamo T., Centra F., Manzorra M. C., Trombetta D., Pantalone A., Bonfitto A., Maiello E., Fazio V. M., Muscarella L. A. |
| المساهمون: | Sparaneo A., Fabrizio F.P., la Torre A., Graziano P., Di Maio M., Fontana A., Bisceglia M., Rossi A., Pizzolitto S., De Maglio G., Tancredi A., Grimaldi F., Balsamo T., Centra F., Manzorra M.C., Trombetta D., Pantalone A., Bonfitto A., Maiello E., Fazio V.M., Muscarella L.A. |
| سنة النشر: | 2019 |
| المجموعة: | Università degli studi di Torino: AperTo (Archivio Istituzionale ad Accesso Aperto) |
| مصطلحات موضوعية: | KEAP1, Lung Carcinoid, NRF2, methylation, mutation, outcome, Adult, Cell Line, Tumor, DNA Methylation, Female, Human, Kelch-Like ECH-Associated Protein 1, Lung Neoplasm, Male, Middle Aged, NF-E2-Related Factor 2, Neuroendocrine Tumor, Young Adult, Gene Expression Regulation, Neoplastic |
| الوصف: | Background. The KEAP1/NRF2 pathway has been widely investigated in tumors since it was implicated in cancer cells survival and therapies resistance. In lung tumors the deregulation of this pathway is mainly related to point mutations of KEAP1 and NFE2L2 genes and KEAP1 promoter hypermethylation, but these two genes have been rarely investigated in low/intermediate grade neuroendocrine tumors of the lung. Methods. The effects of KEAP1 silencing on NRF2 activity was investigated in H720 and H727 carcinoid cell lines and results were compared with those obtained by molecular profiling of KEAP1 and NFE2L2 in a collection of 47 lung carcinoids. The correlation between methylation and transcript levels was assessed by 5-aza-dC treatment. Results. We demonstrated that in carcinoid cell lines, the KEAP1 silencing induces an upregulation of. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/31126053; info:eu-repo/semantics/altIdentifier/wos/WOS:000471001400162; volume:20; issue:10; firstpage:2531; lastpage:2548; numberofpages:18; journal:INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; http://hdl.handle.net/2318/1729974; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85066926627; https://www.mdpi.com/1422-0067/20/10/2531/pdf |
| DOI: | 10.3390/ijms20102531 |
| الاتاحة: | http://hdl.handle.net/2318/1729974 https://doi.org/10.3390/ijms20102531 https://www.mdpi.com/1422-0067/20/10/2531/pdf |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.D5963991 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/ijms20102531 |
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