التفاصيل البيبلوغرافية
| العنوان: |
Randomized phase II trial of iproplatin and carboplatin in advanced breast cancer |
| المؤلفون: |
Vermorken, J. B., Gundersen, S., Clavel, M., Smyth, J. F., Dodion, P., Renard, J., Kaye, S. B., For the EORTC Early Clinical Trials Group and the EORTC Data Center |
| بيانات النشر: |
Oxford University Press |
| سنة النشر: |
1993 |
| المجموعة: |
HighWire Press (Stanford University) |
| مصطلحات موضوعية: |
Original articles |
| الوصف: |
Background: The observed activity of cisplatin in breast cancer and its unattractive toxicity profile in palliative treatment warranted further study of platinum analogues in this disease. Patients and methods: Sixty-two patients with recurrent or metastatic breast cancer, 61 of whom had been previously treated with chemotherapy, were randomly assigned to therapy with either iproplatin (n = 32) or carboplatin (n = 30). Both platinum analogues were administered intravenously, iproplatin at a dose of 240 mg/m2 every 4 weeks and carboplatin at a dose of 450 mg/m2 every 5 weeks. Results: Only two patients responded to iproplatin (7%) for durations of 21 and 61 weeks, and one patient responded to carboplatin (3%) for a duration of 64 weeks. All responses were complete. At the given dose schedules carboplatin was more myelosuppressive than iproplatin. Non-hematologic toxicities included nausea and vomiting (93% vs. 90%), diarrhea (20% vs. 10%) and hemorrhage (16% vs. 10%) for iproplatin and carboplatin, respectively. Two patients developed alopecia with carboplatin. No renal toxicity was observed. Conclusions: Both iproplatin and carboplatin have limited activity in previously treated women with advanced breast cancer when given in conventional dosages. |
| نوع الوثيقة: |
text |
| وصف الملف: |
text/html |
| اللغة: |
English |
| Relation: |
http://annonc.oxfordjournals.org/cgi/content/short/4/4/303 |
| الاتاحة: |
http://annonc.oxfordjournals.org/cgi/content/short/4/4/303 |
| Rights: |
Copyright (C) 1993, European Society for Medical Oncology |
| رقم الانضمام: |
edsbas.D38C24D0 |
| قاعدة البيانات: |
BASE |