Academic Journal
Synthesis, Characterization, and Antioxidant, Antimicrobial and Toxic Properties of Novel Δ2 -1,3,4-thiadiazoline and Δ2 -1,3,4-selenadiazoline Derivatives
| العنوان: | Synthesis, Characterization, and Antioxidant, Antimicrobial and Toxic Properties of Novel Δ2 -1,3,4-thiadiazoline and Δ2 -1,3,4-selenadiazoline Derivatives |
|---|---|
| المؤلفون: | Al-Khazragie, Zainab K, Al-Salami, Bushra K, Al-Fartosy, Adnan J. M |
| المصدر: | INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY; Vol 12 No 01 (2022): International Journal of Drug Delivery Technology(2022);; 113-126 ; 0975-4415 |
| بيانات النشر: | Dr. Yashwant Research Labs Pvt. Ltd. |
| سنة النشر: | 2022 |
| المجموعة: | MRJ - MyResearchJournals (MRI Publications Lucknow, Uttar Pradesh, India) |
| الوصف: | Two new series of N-(4-acetyl-5-aryl-4,5-dihydro-1,3,4-thiadiazol-2-yl)acetamide and N-(4-acetyl-5-aryl-4,5-dihydro1,3,4-selenadiazol-2-yl)acetamide compounds (where aryl = 4-nitrophenyl, 4-hydroxy-3-methoxyphenyl, 3-ethoxy-4- hydroxyphenyl, 2-chloroquinolinyl, and 6-chloro-4-oxo-4H-chromenyl) were synthesized in good yields by heterocyclization of thiosemicarbazones (TSCs) and selenosemicarbazones (SSCs) with acetic anhydride, respectively. The new TSCs and SSCs compounds was prepared by condensation reaction of thiosemicarbazide and Selenosemicarbazide with aromatic aldehydes in acidic medium. The structures of newly synthesized 1,3,4-thiadiazoline (TDZs) and 1,3,4-selenadiazoline (SDZs) derivatives were characterized by the analytical and spectroscopic method such as IR, 1 H NMR, 13C NMR, mass spectra and elemental analysis. The purity of compound and evaluation of Rf value were determined by TLC. The toxicity of new compounds was assayed via the determination of their LD50 value by using Dixon’ s up and down method. The antibacterial activity of 1,3,4-thiadiazoline and 1,3,4-selenadiazoline compounds were tested in vitro against Staphylococcus aureus, Bacillus, Escherichia coli and Pseudomonas aeruginosa. Finally, antioxidant efficiency of all compounds were detected according to β-carotene bleaching method. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| Relation: | https://myresearchjournals.com/index.php/IJDDT/article/view/10964 |
| DOI: | 10.25258/ijddt.12.1.22 |
| الاتاحة: | https://myresearchjournals.com/index.php/IJDDT/article/view/10964 https://doi.org/10.25258/ijddt.12.1.22 |
| Rights: | Copyright (c) 2022 Journal of Advanced Scientific Research ; http://creativecommons.org/licenses/by-nc-nd/4.0 |
| رقم الانضمام: | edsbas.D286A419 |
| قاعدة البيانات: | BASE |
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