Academic Journal
Transcriptome analyses describe the consequences of persistent HIF-1 over-activation in Caenorhabditis elegans
| العنوان: | Transcriptome analyses describe the consequences of persistent HIF-1 over-activation in Caenorhabditis elegans |
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| المؤلفون: | Feng, Dingxia, Qu, Long, Powell-Coffman, Jo Anne |
| المساهمون: | Genetics, Development and Cell Biology, Statistics |
| المصدر: | https://doi.org/10.1371/journal.pone.0295093. |
| بيانات النشر: | Public Library of Science |
| سنة النشر: | 2024 |
| المجموعة: | Digital Repository @ Iowa State University |
| مصطلحات موضوعية: | DegreeDisciplines::Life Sciences::Genetics and Genomics |
| الوصف: | Metazoan animals rely on oxygen for survival, but during normal development and homeostasis, animals are often challenged by hypoxia (low oxygen). In metazoans, many of the critical hypoxia responses are mediated by the evolutionarily conserved hypoxia-inducible transcription factors (HIFs). The stability and activity of HIF complexes are strictly regulated. In the model organism C. elegans, HIF-1 stability and activity are negatively regulated by VHL-1, EGL-9, RHY-1 and SWAN-1. Importantly, C. elegans mutants carrying strong loss-of-function mutations in these genes are viable, and this provides opportunities to interrogate the molecular consequences of persistent HIF-1 over-activation. We find that the genome-wide gene expression patterns are compellingly similar in these mutants, supporting models in which RHY-1, VHL-1 and EGL-9 function in common pathway(s) to regulate HIF-1 activity. These studies illuminate the diversified biological roles played by HIF-1, including metabolism and stress response. Genes regulated by persistent HIF-1 over-activation overlap with genes responsive to pathogens, and they overlap with genes regulated by DAF-16. As crucial stress regulators, HIF-1 and DAF-16 converge on key stress-responsive genes and function synergistically to enable hypoxia survival. ; This article is published as Feng D, Qu L, Powell-Coffman JA (2024) Transcriptome analyses describe the consequences of persistent HIF-1 over-activation in Caenorhabditis elegans. PLoS ONE 19(3): e0295093. https://doi.org/10.1371/journal.pone.0295093. © 2024 Feng et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | https://dr.lib.iastate.edu/handle/20.500.12876/6wBlZxqr |
| الاتاحة: | https://dr.lib.iastate.edu/handle/20.500.12876/6wBlZxqr https://hdl.handle.net/20.500.12876/6wBlZxqr |
| رقم الانضمام: | edsbas.D0856E71 |
| قاعدة البيانات: | BASE |
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