Academic Journal
Phencyclidine (PCP)-Induced Disruption in Cognitive Performance is Gender-Specific and Associated with a Reduction in Brain-Derived Neurotrophic Factor (BDNF) in Specific Regions of the Female Rat Brain
| العنوان: | Phencyclidine (PCP)-Induced Disruption in Cognitive Performance is Gender-Specific and Associated with a Reduction in Brain-Derived Neurotrophic Factor (BDNF) in Specific Regions of the Female Rat Brain |
|---|---|
| المؤلفون: | Shikha Snigdha, Joanna C. Neill, Samantha L. Mclean, Gaurav K. Shemar, Leonie Cruise, Mohammed Shahid, Brian Henry, L. Cruise, M. Shahid, B. Henry |
| المساهمون: | The Pennsylvania State University CiteSeerX Archives |
| المصدر: | ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/15/46/J_Mol_Neurosci_2011_Mar_18_43(3)_337-345.tar.gz |
| سنة النشر: | 2010 |
| المجموعة: | CiteSeerX |
| الوصف: | The Author(s) 2010. This article is published with open access at Springerlink.com Abstract Phencyclidine (PCP), used to mimic certain aspects of schizophrenia, induces sexually dimorphic, cognitive deficits in rats. In this study, the effects of sub-chronic PCP on expression of brain-derived neurotrophic factor (BDNF), a neurotrophic factor implicated in the pathogenesis of schizophrenia, have been evaluated in male and female rats. Male and female hooded-Lister rats received vehicle or PCP (n=8 per group; 2 mg/kg i.p. twice daily for 7 days) and were tested in the attentional set shifting task prior to being sacrificed (6 weeks post-treatment). Levels of BDNF mRNA were measured in specific brain regions using in situ hybridisation. Male rats were less sensitive to PCP-induced deficits in the extra-dimensional shift stage of the attentional set shifting task compared to female rats. Quantitative analysis of brain regions demonstrated reduced BDNF levels in the medial prefrontal cortex (p<0.05), motor cortex (p<0.01), orbital cortex (p<0.01), olfactory bulb (p<0.05), retrosplenial |
| نوع الوثيقة: | text |
| وصف الملف: | application/zip |
| اللغة: | English |
| Relation: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.293.6345 |
| الاتاحة: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.293.6345 |
| Rights: | Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: | edsbas.CD4608E8 |
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