Academic Journal
Kainate, N-methylaspartate and other excitatory amino acids increase calcium influx into rat brain cortex cells in vitro
| العنوان: | Kainate, N-methylaspartate and other excitatory amino acids increase calcium influx into rat brain cortex cells in vitro |
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| المؤلفون: | Berdichevsky, Elisa, Riveros, Nora, Sánchez-Armáss, Sergio, Orrego, Fernando |
| المصدر: | Neuroscience Letters |
| سنة النشر: | 1983 |
| المجموعة: | Universidad de Chile: Repositorio académico |
| مصطلحات موضوعية: | brain cortex, calcium influx, glutamic acid, ibotenic acid, kainic acid, N-acetylaspartic acid, N-methyl-aspartic acid, neurotoxicity |
| الوصف: | Kainate (0.62-5 mM) was found to increase the initial rate of influx of 45Ca and of 22Na into the non-inulin space of rat thin brain cortex slices incubated in vitro, and to shorten the equilibration time for both these ions. N-methyl-dl-aspartate (50-1000 μM), l-glutamate (0.62-5 mM), dl-homocysteate (0.62-2.5 mM), and ibotenate (6-170 μM) also significantly increased the influx of 45Ca into the non-inulin space of this preparation, while the non-neurotoxic acidic amino N-acetyl-l-aspartate, and α-methy-dl-aspartate (both 1.25-5 mM), did not increase such influx. We suggest that enhanced calcium uptaje may represent the basis for the neurotoxic effects of these compounds. © 1983. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 03043940 |
| Relation: | Neuroscience Letters, Volumen 36, Issue 1, 2018, Pages 75-80; https://repositorio.uchile.cl/handle/2250/157672 |
| DOI: | 10.1016/0304-3940(83)90489-5 |
| الاتاحة: | https://doi.org/10.1016/0304-3940(83)90489-5 https://repositorio.uchile.cl/handle/2250/157672 |
| Rights: | Attribution-NonCommercial-NoDerivs 3.0 Chile ; http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ |
| رقم الانضمام: | edsbas.C87CCD70 |
| قاعدة البيانات: | BASE |
| تدمد: | 03043940 |
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| DOI: | 10.1016/0304-3940(83)90489-5 |