Academic Journal
Nanoparticle-Mediated Delivery of Flavonoids: Impact on Proinflammatory Cytokine Production: A Systematic Review
| العنوان: | Nanoparticle-Mediated Delivery of Flavonoids: Impact on Proinflammatory Cytokine Production: A Systematic Review |
|---|---|
| المؤلفون: | Jazmín Cristina Stevens Barrón, Christian Chapa González, Emilio Álvarez Parrilla, Laura Alejandra De la Rosa |
| المصدر: | Biomolecules; Volume 13; Issue 7; Pages: 1158 |
| بيانات النشر: | Multidisciplinary Digital Publishing Institute |
| سنة النشر: | 2023 |
| المجموعة: | MDPI Open Access Publishing |
| مصطلحات موضوعية: | flavonoid, nanoparticle, drug delivery, inflammation, release, cytokine, encapsulation, bioavailability, in vitro, in vivo |
| جغرافية الموضوع: | agris |
| الوصف: | Flavonoids are a diverse group of plant-derived compounds that have been shown to have various health benefits, including anti-inflammatory effects. However, their use in the treatment of inflammatory diseases has been limited due to their low bioavailability. The nanoparticle-mediated delivery of flavonoids has been proposed as a potential solution to this issue, as it allows the sustained release of the flavonoids over time. There are several different nanoparticle systems that have been developed for flavonoid delivery, including polymeric nanoparticles, liposomes, and inorganic nanoparticles. This systematic review aims to evaluate the impact of nanoparticle-mediated delivery of flavonoids on pro-inflammatory cytokine production in various diseases. We analyzed the performance of flavonoid-encapsulated nanoparticles in regulating cytokine production in different in vitro and in vivo studies. To this end, we followed the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) to conduct a comprehensive search of the literature and to assess the quality of the included studies. The results showed that flavonoid-encapsulated nanoparticles significantly downregulated pro-inflammatory cytokines, such as TNF-α, IL-1β, IL-6, and IL-18. In some cases, this effect was significantly greater than that observed with non-encapsulated flavonoids These findings suggest that nanoparticle-mediated delivery of flavonoids may have potential as a therapeutic approach for the treatment of inflammatory diseases. |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | Molecular Medicine; https://dx.doi.org/10.3390/biom13071158 |
| DOI: | 10.3390/biom13071158 |
| الاتاحة: | https://doi.org/10.3390/biom13071158 |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.C808BF9D |
| قاعدة البيانات: | BASE |
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