Academic Journal
Primary penile melanoma and genital lichen sclerosus
| العنوان: | Primary penile melanoma and genital lichen sclerosus |
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| المؤلفون: | Dear, Kate, Kravvas, Georgios, Sim, Sharmaine, Mastoraki, Evanthia, James, Mariel, Watchorn, Richard, Haider, Aiman, Ellery, Peter, Freeman, Alex, Alnajjar, Hussain M., Muneer, Asif, Bunker, Christopher B. |
| المساهمون: | British Skin Foundation |
| المصدر: | Skin Health and Disease ; volume 3, issue 6 ; ISSN 2690-442X 2690-442X |
| بيانات النشر: | Wiley |
| سنة النشر: | 2023 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Background There is a well‐established association between squamous cell cancer and genital lichen sclerosus (GLSc). Although there have been several reported cases of vulval melanoma (MM) associated with LSc, particularly in the paediatric population, fewer cases of male genital (M) GLSc and penile (Pe)MM have been published. Objectives The aim of this study was to explore further the relationship between PeMM and MGLSc by reviewing all the cases managed by our multidisciplinary service over a finite period. Methods All patients known to our tertiary urology and male genital dermatology service with a diagnosis of PeMM and where histology was available for review were identified over an 11‐year period (2011–2022). The histology was reviewed by two independent, mutually ‘blinded’ histopathologists. Photographs and clinical notes, where available, were retrospectively reviewed by two independent dermatologists for signs or symptoms of LSc. Results Eleven patients with PeMM were identified for review. Histopathological examination found evidence of LSc in nine patients, and review of clinical photos corroborated the presence of LSc in three. Overall, features of LSc were present in nine out of eleven cases (82%). Conclusion The presence of LSc in 9 out of 11 cases of PeMM is suggestive of a causative relationship between LSc and PeMM. This may be due to chronic melanocytic distress created by chronic inflammation secondary to LSc. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/ski2.274 |
| الاتاحة: | http://dx.doi.org/10.1002/ski2.274 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ski2.274 |
| Rights: | http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.C76EAA51 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/ski2.274 |
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