Academic Journal
A Two-Gene Balance Regulates Salmonella Typhimurium Tolerance in the Nematode Caenorhabditis elegans
| العنوان: | A Two-Gene Balance Regulates Salmonella Typhimurium Tolerance in the Nematode Caenorhabditis elegans |
|---|---|
| المؤلفون: | Elizabeth K. Marsh, Robin C. May |
| المساهمون: | The Pennsylvania State University CiteSeerX Archives |
| المصدر: | ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/19/a5/PLoS_One_2011_Mar_2_6(3)_e16839.tar.gz |
| سنة النشر: | 2010 |
| المجموعة: | CiteSeerX |
| الوصف: | Lysozymes are antimicrobial enzymes that perform a critical role in resisting infection in a wide-range of eukaryotes. However, using the nematode Caenorhabditis elegans as a model host we now demonstrate that deletion of the protist type lysozyme LYS-7 renders animals susceptible to killing by the fatal fungal human pathogen Cryptococcus neoformans, but, remarkably, enhances tolerance to the enteric bacteria Salmonella Typhimurium. This trade-off in immunological susceptibility in C. elegans is further mediated by the reciprocal activity of lys-7 and the tyrosine kinase abl-1. Together this implies a greater complexity in C. elegans innate immune function than previously thought. |
| نوع الوثيقة: | text |
| وصف الملف: | application/zip |
| اللغة: | English |
| Relation: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.293.4533 |
| الاتاحة: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.293.4533 |
| Rights: | Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
| رقم الانضمام: | edsbas.C5E08F23 |
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