Academic Journal
Chemical composition, antioxidant potential, and blood glucose lowering effect of aqueous extract and essential oil of Thymus Serrulatus Hochst. Ex Benth
| العنوان: | Chemical composition, antioxidant potential, and blood glucose lowering effect of aqueous extract and essential oil of Thymus Serrulatus Hochst. Ex Benth |
|---|---|
| المؤلفون: | Haile, Tesfay, Cardoso, Susana M., Raphaelli, Chirle de Oliveira, Pereira, Olívia R., Pereira, Elisa dos Santos, Vizzotto, Márcia, Nora, Leonardo, Asfaw, Adissu Alemayehu, Periasamy, Gomathi, Karim, Aman |
| بيانات النشر: | Frontiers |
| سنة النشر: | 2021 |
| المجموعة: | Biblioteca Digital do Instituto Politécnico de Bragança (IPB) |
| مصطلحات موضوعية: | Antioxidant activity, Essential oil, Thyme-decoction, Alpha-amylase, Thymus serrulatus, Alphaglucosidase, Phenolic compounds profile, Antihyperglycemic activity |
| الوصف: | Thymus serrulatus, an endemic plant of Ethiopia, is traditionally used to cure various diseases and as a food ingredient. In the Ethiopian folk medicine, the decoction is orally taken as a remedy to treat diabetes and high blood pressure. The purpose of the present study was to evaluate the antioxidant and antihyperglycemic effects of the aqueous extract and of the essential oil of Thymus serrulatus. The chemical composition of the aqueous extract was determined by LC-MS and the essential oil was characterized by GC-MS analysis. Radical scavenging assays, namely scavenging of 2,2-diphenyl-1-picrylhydrazyl (DPPH•), hydroxyl (•OH), and nitric oxide (•NO), were used as a first approach to screen the potential antioxidant abilities of the samples. Alpha-amylase and α-glucosidase inhibitory studies were also employed to evaluate the in vitro antihyperglycemic potential of the plant. The in vivo blood glucose lowering effect of the extracts was assessed using hypoglycemic activity and the oral glucose tolerance test in normal and in streptozotocin induced diabetic mice. When compared to the aqueous extract, the essential oil showed superior radical scavenging activity, particularly for •NO, as well as greater inhibitory potency against α-amylase and α-glucosidase (IC50 = 0.01 mg/ml and 0.11 mg/ml, respectively). Both tested samples showed a statistically significant antihyperglycemic effect. The aqueous extract at 600 mg/kg exerted maximum antihyperglycemic activity (44.14%), followed by the essential oil (30.82%). Body weight and glucose tolerance parameters were also improved by the samples both in normal and diabetic mice. The findings of this study support the hypothesis that aqueous extract and essential oil of T. serrulatus are promising therapeutic agents. ; This study was supported by a financial grant obtained from MU-NMBU project of Mekelle University (PG/MSc/MU-NMBU/CHS/55/2011) for data collection only. Authors acknowledge Mekelle University, Ethiopia for providing necessary facilities and also thank ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1663-9812 |
| Relation: | Haile, Tesfay; Cardoso, Susana M.; Raphaelli, Chirle de Oliveira; Pereira, Olívia R.; Pereira, Elisa dos Santos; Vizzotto, Márcia; Nora, Leonardo; Asfaw, Adissu Alemayehu; Periasamy, Gomathi; Karim, Aman (2021). Chemical composition, antioxidant potential, and blood glucose lowering effect of aqueous extract and essential oil of Thymus Serrulatus Hochst. Ex Benth. Frontiers in Pharmacology. ISSN 1663-9812. 12, p. 1-14; http://hdl.handle.net/10198/23656 |
| DOI: | 10.3389/fphar.2021.621536 |
| الاتاحة: | http://hdl.handle.net/10198/23656 https://doi.org/10.3389/fphar.2021.621536 |
| Rights: | openAccess ; http://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.C5733E5C |
| قاعدة البيانات: | BASE |
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In the Ethiopian folk medicine, the decoction is orally taken as a remedy to treat diabetes and high blood pressure. The purpose of the present study was to evaluate the antioxidant and antihyperglycemic effects of the aqueous extract and of the essential oil of Thymus serrulatus. The chemical composition of the aqueous extract was determined by LC-MS and the essential oil was characterized by GC-MS analysis. Radical scavenging assays, namely scavenging of 2,2-diphenyl-1-picrylhydrazyl (DPPH•), hydroxyl (•OH), and nitric oxide (•NO), were used as a first approach to screen the potential antioxidant abilities of the samples. Alpha-amylase and α-glucosidase inhibitory studies were also employed to evaluate the in vitro antihyperglycemic potential of the plant. The in vivo blood glucose lowering effect of the extracts was assessed using hypoglycemic activity and the oral glucose tolerance test in normal and in streptozotocin induced diabetic mice. When compared to the aqueous extract, the essential oil showed superior radical scavenging activity, particularly for •NO, as well as greater inhibitory potency against α-amylase and α-glucosidase (IC50 = 0.01 mg/ml and 0.11 mg/ml, respectively). Both tested samples showed a statistically significant antihyperglycemic effect. The aqueous extract at 600 mg/kg exerted maximum antihyperglycemic activity (44.14%), followed by the essential oil (30.82%). Body weight and glucose tolerance parameters were also improved by the samples both in normal and diabetic mice. The findings of this study support the hypothesis that aqueous extract and essential oil of T. serrulatus are promising therapeutic agents. ; This study was supported by a financial grant obtained from MU-NMBU project of Mekelle University (PG/MSc/MU-NMBU/CHS/55/2011) for data collection only. 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