Academic Journal
Crossbred Sows Fed a Western Diet during Pre-Gestation, Gestation, Lactation, and Post-Lactation Periods Develop Signs of Lean Metabolic Syndrome That Are Partially Attenuated by Spirulina Supplementation
| العنوان: | Crossbred Sows Fed a Western Diet during Pre-Gestation, Gestation, Lactation, and Post-Lactation Periods Develop Signs of Lean Metabolic Syndrome That Are Partially Attenuated by Spirulina Supplementation |
|---|---|
| المؤلفون: | Rosamaria Lugarà, Simone Renner, Eckhard Wolf, Annette Liesegang, Rupert Bruckmaier, Katrin Giller |
| المصدر: | Nutrients; Volume 14; Issue 17; Pages: 3574 |
| بيانات النشر: | Multidisciplinary Digital Publishing Institute |
| سنة النشر: | 2022 |
| المجموعة: | MDPI Open Access Publishing |
| مصطلحات موضوعية: | dietary fat, dietary sugar, microalgae, gene expression, liver steatosis, skeletal muscle, insulin-like growth factor, pig model |
| جغرافية الموضوع: | agris |
| الوصف: | Excessive dietary intake of fats and sugars (“Western diet”, WD) is one of the leading causes of obesity. The consumption of the microalga Arthrospira platensis (spirulina, Sp) is increasing due to its presumed health benefits. Both WD and Sp are also consumed by pregnant and breastfeeding women. This study investigated if gestating and lactating domestic pigs are an appropriate model for WD-induced metabolic disturbances similar to those observed in humans and if Sp supplementation may attenuate any of these adverse effects. Pigs were fed a WD high in fat, sugars, and cholesterol or a control diet. Half of the animals per diet group were supplemented with 20 g Sp per day. The WD did not increase body weight or adipose tissue accumulation but led to metabolic impairments such as higher cholesterol concentration in plasma, lower IGF1 plasma levels, and signs of hepatic damage compared to the control group. Spirulina supplementation could not reduce all the metabolic impairments observed in WD-fed animals. These findings indicate limited suitability of gestating and lactating domestic pigs as a model for WD but a certain potential of low-dose Sp supplementation to partially attenuate negative WD effects. |
| نوع الوثيقة: | text |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | Nutritional Epidemiology; https://dx.doi.org/10.3390/nu14173574 |
| DOI: | 10.3390/nu14173574 |
| الاتاحة: | https://doi.org/10.3390/nu14173574 |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.C2FBA9AB |
| قاعدة البيانات: | BASE |
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