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B-cell malignancies treated with targeted drugs and SARS-CoV-2 infection: A European Hematology Association Survey (EPICOVIDEHA)

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العنوان: B-cell malignancies treated with targeted drugs and SARS-CoV-2 infection: A European Hematology Association Survey (EPICOVIDEHA)
المؤلفون: Infante, Maria Stefania, Salmanton-García, Jon, Fernández-Cruz, Ana, Marchesi, Francesco, Jakšić, Ozren, Weinbergerová, Barbora, Besson, Caroline, Duarte, Rafael F., Itri, Federico, Valković, Toni, Szotkovski, Tomáš, Busca, Alessandro, Guidetti, Anna, Glenthøj, Andreas, Collins, Graham P., Bonuomo, Valentina, Sili, Uluhan, Seval, Guldane Cengiz, Machado, Marina, Cordoba, Raul, Blennow, Ola, Abu-Zeinah, Ghaith, Lamure, Sylvain, Kulasekararaj, Austin, Falces-Romero, Iker, Cattaneo, Chiara, Van Doesum, Jaap, Piukovics, Klára, Omrani, Ali S., Magliano, Gabriele, Ledoux, Marie-Pierre, de Ramon, Cristina, Cabirta, Alba, Verga, Luisa, López-García, Alberto, Da Silva, Maria Gomes, Stojanoski, Zlate, Meers, Stef, Lahmer, Tobias, Martín-Pérez, Sonia, Dávila-Vals, Julio, Van Praet, Jens, Samarkos, Michail, Bilgin, Yavuz M., Karlsson, Linda Katharina, Batinić, Josip, Nordlander, Anna, Schönlein, Martin, Hoenigl, Martin, Ráčil, Zdeněk, Mladenović, Miloš, Hanakova, Michaela, Zambrotta, Giovanni Paolo Maria, De Jonge, Nick, Adžić-Vukičević, Tatjana, Nunes-Rodrigues, Raquel, Prezioso, Lucia, Navrátil, Milan, Marchetti, Monia, Cuccaro, Annarosa, Calbacho, Maria, Giordano, Antonio, Cornely, Oliver A., Hernández-Rivas, José-Ángel, Pagano, Livio
المصدر: https://www.frontiersin.org/articles/10.3389/fonc.2022.992137/full ; Frontiers in Oncology ; Volume 12 ; ISSN 2234-943X (Online.
سنة النشر: 2022
المجموعة: Repository of the University of Rijeka
مصطلحات موضوعية: SARS-CoV-2, chronic lymphocytic leukemia (CLL), immune system COVID19, infection risk, lymphoproliferative diseases (LPD), non-Hodgkin lymphoma (NHL), targeted drugs, BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Interna medicina, BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Internal Medicine, BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Infektologija, BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Infectology, BIOMEDICINA I ZDRAVSTVO. Kliničke medicinske znanosti. Onkologija, BIOMEDICINE AND HEALTHCARE. Clinical Medical Sciences. Oncology
الوصف: Patients with lymphoproliferative diseases (LPD) are vulnerable to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Here, we describe and analyze the outcome of 366 adult patients with chronic lymphocytic leukemia (CLL) or non-Hodgkin Lymphoma (NHL) treated with targeted drugs and laboratory-confirmed COVID-19 diagnosed between February 2020 and January 2022. Median follow-up was 70.5 days (IQR 0-609). Most used targeted drugs were Bruton-kinase inhibitors (BKIs) (N= 201, 55%), anti-CD20 other than rituximab (N=61, 16%), BCL2 inhibitors (N=33, 9%) and lenalidomide (N=28, 8%).Only 16.2% of the patients were vaccinated with 2 or more doses of vaccine at the onset of COVID-19. Mortality was 24% (89/366) on day 30 and 36%(134/366) on the last day of follow-up. Age >75 years (p<0.001, HR 1.036), active malignancy (p<0.001, HR 2.215), severe COVID-19 (p=0.017, HR 2.270) and admission to ICU (p<0.001, HR 5.751) were risk factors for mortality at last day of follow up. There was no difference in OS rates in NHL vs CLL patients (p=0.306), nor in patients treated with or without BKIs (p=0.151). Mortality in ICU was 66% (CLL 61%, NHL 76%). Overall mortality rate decreased according to vaccination status, being 39% in unvaccinated patients, 32% and 26% in those having received one or two doses, respectively, and 20% in patients with a booster dose (p=0.245). Overall mortality rate dropped from 41% during the first semester of 2020 to 25% at the last semester of 2021. These results show increased severity and mortality from COVID-19 in LPDs patients treated with targeted drugs.
نوع الوثيقة: article in journal/newspaper
وصف الملف: application/pdf
اللغة: English
Relation: Sveučilište u Rijeci. Medicinski fakultet. Katedra za internu medicinu.; University of Rijeka. Faculty of Medicine. Department of Internal Medicine.; https://www.unirepository.svkri.uniri.hr/islandora/object/medri:6975; https://urn.nsk.hr/urn:nbn:hr:184:658338; https://www.unirepository.svkri.uniri.hr/islandora/object/medri:6975/datastream/FILE0
الاتاحة: https://www.unirepository.svkri.uniri.hr/islandora/object/medri:6975
https://urn.nsk.hr/urn:nbn:hr:184:658338
https://www.unirepository.svkri.uniri.hr/islandora/object/medri:6975/datastream/FILE0
Rights: info:eu-repo/semantics/openAccess ; http://rightsstatements.org/vocab/InC/1.0/
رقم الانضمام: edsbas.C072DCBE
قاعدة البيانات: BASE
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Array ( [Name] => Abstract [Label] => Description [Group] => Ab [Data] => Patients with lymphoproliferative diseases (LPD) are vulnerable to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Here, we describe and analyze the outcome of 366 adult patients with chronic lymphocytic leukemia (CLL) or non-Hodgkin Lymphoma (NHL) treated with targeted drugs and laboratory-confirmed COVID-19 diagnosed between February 2020 and January 2022. Median follow-up was 70.5 days (IQR 0-609). Most used targeted drugs were Bruton-kinase inhibitors (BKIs) (N= 201, 55%), anti-CD20 other than rituximab (N=61, 16%), BCL2 inhibitors (N=33, 9%) and lenalidomide (N=28, 8%).Only 16.2% of the patients were vaccinated with 2 or more doses of vaccine at the onset of COVID-19. Mortality was 24% (89/366) on day 30 and 36%(134/366) on the last day of follow-up. Age &gt;75 years (p&lt;0.001, HR 1.036), active malignancy (p&lt;0.001, HR 2.215), severe COVID-19 (p=0.017, HR 2.270) and admission to ICU (p&lt;0.001, HR 5.751) were risk factors for mortality at last day of follow up. There was no difference in OS rates in NHL vs CLL patients (p=0.306), nor in patients treated with or without BKIs (p=0.151). Mortality in ICU was 66% (CLL 61%, NHL 76%). Overall mortality rate decreased according to vaccination status, being 39% in unvaccinated patients, 32% and 26% in those having received one or two doses, respectively, and 20% in patients with a booster dose (p=0.245). Overall mortality rate dropped from 41% during the first semester of 2020 to 25% at the last semester of 2021. These results show increased severity and mortality from COVID-19 in LPDs patients treated with targeted drugs. )
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