Academic Journal
Geographic distribution of methyltransferases of Helicobacter pylori: evidence of human host population isolation and migration.
| العنوان: | Geographic distribution of methyltransferases of Helicobacter pylori: evidence of human host population isolation and migration. |
|---|---|
| المؤلفون: | Vale, Filipa, Mégraud, Francis, Vítor, Jorge |
| المساهمون: | Engineering Faculty, Portuguese Catholic University, Infection à helicobacter, inflammation et cancer, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM), iMed.UL (MedChem Division), Universidade de Lisboa = University of Lisbon = Université de Lisbonne (ULISBOA), This work was partially supported by New England Biolabs, Inc. (USA). |
| المصدر: | ISSN: 1471-2180 ; BMC Microbiology ; https://inserm.hal.science/inserm-00663935 ; BMC Microbiology, 2009, 9 (1), pp.193. ⟨10.1186/1471-2180-9-193⟩. |
| بيانات النشر: | HAL CCSD BioMed Central |
| سنة النشر: | 2009 |
| المجموعة: | Inserm: HAL (Institut national de la santé et de la recherche médicale) |
| مصطلحات موضوعية: | MESH: DNA, Bacterial, MESH: Emigration and Immigration, MESH: Methyltransferases, MESH: Sequence Analysis, DNA, MESH: Genes, MESH: Genetics, Population, MESH: Genome, MESH: Geography, MESH: Helicobacter Infections, MESH: Helicobacter pylori, MESH: Humans, MESH: Logistic Models, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology |
| الوصف: | International audience ; BACKGROUND: Helicobacter pylori colonizes the human stomach and is associated with gastritis, peptic ulcer, and gastric cancer. This ubiquitous association between H. pylori and humans is thought to be present since the origin of modern humans. The H. pylori genome encodes for an exceptional number of restriction and modifications (R-M) systems. To evaluate if R-M systems are an adequate tool to determine the geographic distribution of H. pylori strains, we typed 221 strains from Africa, America, Asia, and Europe, and evaluated the expression of different 29 methyltransferases. RESULTS: Independence tests and logistic regression models revealed that ten R-M systems correlate with geographical localization. The distribution pattern of these methyltransferases may have been originated by co-divergence of regional H. pylori after its human host migrated out of Africa. The expression of specific methyltransferases in the H. pylori population may also reflect the genetic and cultural background of its human host. Methyltransferases common to all strains, M. HhaI and M. NaeI, are likely conserved in H. pylori, and may have been present in the bacteria genome since the human diaspora out of Africa. CONCLUSION: This study indicates that some methyltransferases are useful geomarkers, which allow discrimination of bacterial populations, and that can be added to our tools to investigate human migrations. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/19737407; inserm-00663935; https://inserm.hal.science/inserm-00663935; https://inserm.hal.science/inserm-00663935/document; https://inserm.hal.science/inserm-00663935/file/1471-2180-9-193.pdf; PUBMED: 19737407 |
| DOI: | 10.1186/1471-2180-9-193 |
| الاتاحة: | https://inserm.hal.science/inserm-00663935 https://inserm.hal.science/inserm-00663935/document https://inserm.hal.science/inserm-00663935/file/1471-2180-9-193.pdf https://doi.org/10.1186/1471-2180-9-193 |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.BEA488CF |
| قاعدة البيانات: | BASE |
| ResultId |
1 |
|---|---|
| Header |
edsbas BASE edsbas.BEA488CF 840 3 Academic Journal academicJournal 839.994262695313 |
| PLink |
https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsbas&AN=edsbas.BEA488CF&custid=s6537998&authtype=sso |
| FullText |
Array
(
[Availability] => 0
)
Array ( [0] => Array ( [Url] => https://inserm.hal.science/inserm-00663935# [Name] => EDS - BASE [Category] => fullText [Text] => View record in BASE [MouseOverText] => View record in BASE ) ) |
| Items |
Array
(
[Name] => Title
[Label] => Title
[Group] => Ti
[Data] => Geographic distribution of methyltransferases of Helicobacter pylori: evidence of human host population isolation and migration.
)
Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => <searchLink fieldCode="AR" term="%22Vale%2C+Filipa%22">Vale, Filipa</searchLink><br /><searchLink fieldCode="AR" term="%22Mégraud%2C+Francis%22">Mégraud, Francis</searchLink><br /><searchLink fieldCode="AR" term="%22Vítor%2C+Jorge%22">Vítor, Jorge</searchLink> ) Array ( [Name] => Author [Label] => Contributors [Group] => Au [Data] => Engineering Faculty<br />Portuguese Catholic University<br />Infection à helicobacter, inflammation et cancer<br />Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM)<br />iMed.UL (MedChem Division)<br />Universidade de Lisboa = University of Lisbon = Université de Lisbonne (ULISBOA)<br />This work was partially supported by New England Biolabs, Inc. (USA). ) Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => <i>ISSN: 1471-2180 ; BMC Microbiology ; https://inserm.hal.science/inserm-00663935 ; BMC Microbiology, 2009, 9 (1), pp.193. ⟨10.1186/1471-2180-9-193⟩</i>. ) Array ( [Name] => Publisher [Label] => Publisher Information [Group] => PubInfo [Data] => HAL CCSD<br />BioMed Central ) Array ( [Name] => DatePubCY [Label] => Publication Year [Group] => Date [Data] => 2009 ) Array ( [Name] => Subset [Label] => Collection [Group] => HoldingsInfo [Data] => Inserm: HAL (Institut national de la santé et de la recherche médicale) ) Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => <searchLink fieldCode="DE" term="%22MESH%3A+DNA%22">MESH: DNA</searchLink><br /><searchLink fieldCode="DE" term="%22Bacterial%22">Bacterial</searchLink><br /><searchLink fieldCode="DE" term="%22MESH%3A+Emigration+and+Immigration%22">MESH: Emigration and Immigration</searchLink><br /><searchLink fieldCode="DE" term="%22MESH%3A+Methyltransferases%22">MESH: Methyltransferases</searchLink><br /><searchLink fieldCode="DE" term="%22MESH%3A+Sequence+Analysis%22">MESH: Sequence Analysis</searchLink><br /><searchLink fieldCode="DE" term="%22DNA%22">DNA</searchLink><br /><searchLink fieldCode="DE" term="%22MESH%3A+Genes%22">MESH: Genes</searchLink><br /><searchLink fieldCode="DE" term="%22MESH%3A+Genetics%22">MESH: Genetics</searchLink><br /><searchLink fieldCode="DE" term="%22Population%22">Population</searchLink><br /><searchLink fieldCode="DE" term="%22MESH%3A+Genome%22">MESH: Genome</searchLink><br /><searchLink fieldCode="DE" term="%22MESH%3A+Geography%22">MESH: Geography</searchLink><br /><searchLink fieldCode="DE" term="%22MESH%3A+Helicobacter+Infections%22">MESH: Helicobacter Infections</searchLink><br /><searchLink fieldCode="DE" term="%22MESH%3A+Helicobacter+pylori%22">MESH: Helicobacter pylori</searchLink><br /><searchLink fieldCode="DE" term="%22MESH%3A+Humans%22">MESH: Humans</searchLink><br /><searchLink fieldCode="DE" term="%22MESH%3A+Logistic+Models%22">MESH: Logistic Models</searchLink><br /><searchLink fieldCode="DE" term="%22[SDV%2EMP]Life+Sciences+[q-bio]%2FMicrobiology+and+Parasitology%22">[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology</searchLink> ) Array ( [Name] => Abstract [Label] => Description [Group] => Ab [Data] => International audience ; BACKGROUND: Helicobacter pylori colonizes the human stomach and is associated with gastritis, peptic ulcer, and gastric cancer. This ubiquitous association between H. pylori and humans is thought to be present since the origin of modern humans. The H. pylori genome encodes for an exceptional number of restriction and modifications (R-M) systems. To evaluate if R-M systems are an adequate tool to determine the geographic distribution of H. pylori strains, we typed 221 strains from Africa, America, Asia, and Europe, and evaluated the expression of different 29 methyltransferases. RESULTS: Independence tests and logistic regression models revealed that ten R-M systems correlate with geographical localization. The distribution pattern of these methyltransferases may have been originated by co-divergence of regional H. pylori after its human host migrated out of Africa. The expression of specific methyltransferases in the H. pylori population may also reflect the genetic and cultural background of its human host. Methyltransferases common to all strains, M. HhaI and M. NaeI, are likely conserved in H. pylori, and may have been present in the bacteria genome since the human diaspora out of Africa. CONCLUSION: This study indicates that some methyltransferases are useful geomarkers, which allow discrimination of bacterial populations, and that can be added to our tools to investigate human migrations. ) Array ( [Name] => TypeDocument [Label] => Document Type [Group] => TypDoc [Data] => article in journal/newspaper ) Array ( [Name] => Language [Label] => Language [Group] => Lang [Data] => English ) Array ( [Name] => NoteTitleSource [Label] => Relation [Group] => SrcInfo [Data] => info:eu-repo/semantics/altIdentifier/pmid/19737407; inserm-00663935; https://inserm.hal.science/inserm-00663935; https://inserm.hal.science/inserm-00663935/document; https://inserm.hal.science/inserm-00663935/file/1471-2180-9-193.pdf; PUBMED: 19737407 ) Array ( [Name] => DOI [Label] => DOI [Group] => ID [Data] => 10.1186/1471-2180-9-193 ) Array ( [Name] => URL [Label] => Availability [Group] => URL [Data] => https://inserm.hal.science/inserm-00663935<br />https://inserm.hal.science/inserm-00663935/document<br />https://inserm.hal.science/inserm-00663935/file/1471-2180-9-193.pdf<br />https://doi.org/10.1186/1471-2180-9-193 ) Array ( [Name] => Copyright [Label] => Rights [Group] => Cpyrght [Data] => info:eu-repo/semantics/OpenAccess ) Array ( [Name] => AN [Label] => Accession Number [Group] => ID [Data] => edsbas.BEA488CF ) |
| RecordInfo |
Array
(
[BibEntity] => Array
(
[Identifiers] => Array
(
[0] => Array
(
[Type] => doi
[Value] => 10.1186/1471-2180-9-193
)
)
[Languages] => Array
(
[0] => Array
(
[Text] => English
)
)
[Subjects] => Array
(
[0] => Array
(
[SubjectFull] => MESH: DNA
[Type] => general
)
[1] => Array
(
[SubjectFull] => Bacterial
[Type] => general
)
[2] => Array
(
[SubjectFull] => MESH: Emigration and Immigration
[Type] => general
)
[3] => Array
(
[SubjectFull] => MESH: Methyltransferases
[Type] => general
)
[4] => Array
(
[SubjectFull] => MESH: Sequence Analysis
[Type] => general
)
[5] => Array
(
[SubjectFull] => DNA
[Type] => general
)
[6] => Array
(
[SubjectFull] => MESH: Genes
[Type] => general
)
[7] => Array
(
[SubjectFull] => MESH: Genetics
[Type] => general
)
[8] => Array
(
[SubjectFull] => Population
[Type] => general
)
[9] => Array
(
[SubjectFull] => MESH: Genome
[Type] => general
)
[10] => Array
(
[SubjectFull] => MESH: Geography
[Type] => general
)
[11] => Array
(
[SubjectFull] => MESH: Helicobacter Infections
[Type] => general
)
[12] => Array
(
[SubjectFull] => MESH: Helicobacter pylori
[Type] => general
)
[13] => Array
(
[SubjectFull] => MESH: Humans
[Type] => general
)
[14] => Array
(
[SubjectFull] => MESH: Logistic Models
[Type] => general
)
[15] => Array
(
[SubjectFull] => [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology
[Type] => general
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Geographic distribution of methyltransferases of Helicobacter pylori: evidence of human host population isolation and migration.
[Type] => main
)
)
)
[BibRelationships] => Array
(
[HasContributorRelationships] => Array
(
[0] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Vale, Filipa
)
)
)
[1] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Mégraud, Francis
)
)
)
[2] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Vítor, Jorge
)
)
)
[3] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Engineering Faculty
)
)
)
[4] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Portuguese Catholic University
)
)
)
[5] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Infection à helicobacter, inflammation et cancer
)
)
)
[6] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM)
)
)
)
[7] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => iMed.UL (MedChem Division)
)
)
)
[8] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Universidade de Lisboa = University of Lisbon = Université de Lisbonne (ULISBOA)
)
)
)
[9] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => This work was partially supported by New England Biolabs, Inc. (USA).
)
)
)
)
[IsPartOfRelationships] => Array
(
[0] => Array
(
[BibEntity] => Array
(
[Dates] => Array
(
[0] => Array
(
[D] => 01
[M] => 01
[Type] => published
[Y] => 2009
)
)
[Identifiers] => Array
(
[0] => Array
(
[Type] => issn-locals
[Value] => edsbas
)
[1] => Array
(
[Type] => issn-locals
[Value] => edsbas.oa
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => ISSN: 1471-2180 ; BMC Microbiology ; https://inserm.hal.science/inserm-00663935 ; BMC Microbiology, 2009, 9 (1), pp.193. ⟨10.1186/1471-2180-9-193⟩
[Type] => main
)
)
)
)
)
)
)
|
| IllustrationInfo |