Academic Journal
Phosphotransferase System Uptake and Metabolism of the β-Glucoside Salicin Impact Group A Streptococcal Bloodstream Survival and Soft Tissue Infection
| العنوان: | Phosphotransferase System Uptake and Metabolism of the β-Glucoside Salicin Impact Group A Streptococcal Bloodstream Survival and Soft Tissue Infection |
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| المؤلفون: | Braza, Rezia Era, Silver, Aliyah B., Sundar, Ganesh S., Davis, Sarah E., Razi, Afrooz, Islam, Emrul, Hart, Meaghan, Zhu, Jinyi, Le Breton, Yoann, McIver, Kevin S. |
| المساهمون: | Torres, Victor J., HHS | NIH | National Institute of Allergy and Infectious Diseases |
| المصدر: | Infection and Immunity ; volume 88, issue 10 ; ISSN 0019-9567 1098-5522 |
| بيانات النشر: | American Society for Microbiology |
| سنة النشر: | 2020 |
| الوصف: | Streptococcus pyogenes (group A Streptococcus [GAS]), a major human-specific pathogen, relies on efficient nutrient acquisition for successful infection within its host. The phosphotransferase system (PTS) couples the import of carbohydrates with their phosphorylation prior to metabolism and has been linked to GAS pathogenesis. In a screen of an insertional mutant library of all 14 annotated PTS permease (EIIC) genes in MGAS5005, the annotated β-glucoside PTS transporter ( bglP ) was found to be crucial for GAS growth and survival in human blood and was validated in another M1T1 GAS strain, 5448. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1128/iai.00346-20 |
| DOI: | 10.1128/IAI.00346-20 |
| الاتاحة: | http://dx.doi.org/10.1128/iai.00346-20 https://journals.asm.org/doi/pdf/10.1128/IAI.00346-20 |
| Rights: | https://journals.asm.org/non-commercial-tdm-license |
| رقم الانضمام: | edsbas.BCDE2867 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1128/iai.00346-20 |
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