التفاصيل البيبلوغرافية
| العنوان: |
A Vaccinology Approach to the Identification and Characterization of Dermanyssus gallinae Candidate Protective Antigens for the Control of Poultry Red Mite Infestations |
| المؤلفون: |
José Lima-Barbero, Marinela Contreras, Lourdes Mateos-Hernández, Francisco Mata-Lorenzo, Roxana Triguero-Ocaña, Olivier Sparagano, Robert Finn, Christina Strube, Daniel Price, Francesca Nunn, Kathryn Bartley, Ursula Höfle, Mariana Boadella, Alasdair Nisbet, José de la Fuente, Margarita Villar |
| المصدر: |
Vaccines; Volume 7; Issue 4; Pages: 190 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2019 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
Dermanyssus, poultry red mite, proteomics, vaccine, vaccinology, control, protective antigens |
| الوصف: |
The poultry red mite (PRM), Dermanyssus gallinae, is a hematophagous ectoparasite considered as the major pest in the egg-laying industry. Its pesticide-based control is only partially successful and requires the development of new control interventions such as vaccines. In this study, we follow a vaccinology approach to identify PRM candidate protective antigens. Based on proteomic data from fed and unfed nymph and adult mites, we selected a novel PRM protein, calumenin (Deg-CALU), which is tested as a vaccine candidate on an on-hen trial. Rhipicephalus microplus Subolesin (Rhm-SUB) was chosen as a positive control. Deg-CALU and Rhm-SUB reduced the mite oviposition by 35 and 44%, respectively. These results support Deg-CALU and Rhm-SUB as candidate protective antigens for the PRM control. |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
https://dx.doi.org/10.3390/vaccines7040190 |
| DOI: |
10.3390/vaccines7040190 |
| الاتاحة: |
https://doi.org/10.3390/vaccines7040190 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.B0543F3F |
| قاعدة البيانات: |
BASE |