Academic Journal
From a Natural Polymer to Relevant NAG‐NAM Precursors
| العنوان: | From a Natural Polymer to Relevant NAG‐NAM Precursors |
|---|---|
| المؤلفون: | Carvalho, Luísa C. R., Queda, Fausto, Almeida, Cátia V., Filipe, Sérgio R., Marques, M. Manuel B. |
| المصدر: | Asian Journal of Organic Chemistry ; volume 7, issue 12, page 2544-2551 ; ISSN 2193-5807 2193-5815 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2018 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Herein we report a novel and atom‐economical route towards an advanced intermediate of a synthetically challenging disaccharide of N ‐acetylglucosamine (NAG)‐ N ‐acetylmuramic (NAM) disaccharide units, linked via [NAG‐(β‐1,4)‐NAM] linkage, the basic carbohydrate skeleton of the bacterial peptidoglycan. A simple synthetic scheme was developed in which a fully protected chitobiose, obtained on a gram scale from chitin, was converted into an advanced precursor of NAG‐NAM in 5 steps. The intermediate prepared was obtained from Chitin, a naturally abundant polymer, taking advantage of the chitobiose β‐1,4 glycosidic bond, which avoids a difficult step for the disaccharide assembly. This intermediate constitutes of a versatile scaffold that allows further derivatization, with impact in the glycobiology field. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/ajoc.201800592 |
| الاتاحة: | http://dx.doi.org/10.1002/ajoc.201800592 https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fajoc.201800592 https://onlinelibrary.wiley.com/doi/pdf/10.1002/ajoc.201800592 https://onlinelibrary.wiley.com/doi/full-xml/10.1002/ajoc.201800592 |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.AF4636B |
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