Academic Journal
Going with the flow: insights from Caenorhabditis eleganszygote polarization
| العنوان: | Going with the flow: insights from Caenorhabditis eleganszygote polarization |
|---|---|
| المؤلفون: | Gubieda, Alicia G., Packer, John R., Squires, Iolo, Martin, Jack, Rodriguez, Josana |
| المساهمون: | Biotechnology and Biological Sciences Research Council, Faculty of Medical Sciences, Newcastle University |
| المصدر: | Philosophical Transactions of the Royal Society B: Biological Sciences ; volume 375, issue 1809, page 20190555 ; ISSN 0962-8436 1471-2970 |
| بيانات النشر: | The Royal Society |
| سنة النشر: | 2020 |
| الوصف: | Cell polarity is the asymmetric distribution of cellular components along a defined axis. Polarity relies on complex signalling networks between conserved patterning proteins, including the PAR ( par titioning defective) proteins, which become segregated in response to upstream symmetry breaking cues. Although the mechanisms that drive the asymmetric localization of these proteins are dependent upon cell type and context, in many cases the regulation of actomyosin cytoskeleton dynamics is central to the transport, recruitment and/or stabilization of these polarity effectors into defined subcellular domains. The transport or advection of PAR proteins by an actomyosin flow was first observed in the Caenorhabditis elegan s zygote more than a decade ago. Since then a multifaceted approach, using molecular methods, high-throughput screens, and biophysical and computational models, has revealed further aspects of this flow and how polarity regulators respond to and modulate it. Here, we review recent findings on the interplay between actomyosin flow and the PAR patterning networks in the polarization of the C. elegans zygote. We also discuss how these discoveries and developed methods are shaping our understanding of other flow-dependent polarizing systems. This article is part of a discussion meeting issue ‘Contemporary morphogenesis’. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1098/rstb.2019.0555 |
| الاتاحة: | http://dx.doi.org/10.1098/rstb.2019.0555 https://royalsocietypublishing.org/doi/pdf/10.1098/rstb.2019.0555 https://royalsocietypublishing.org/doi/full-xml/10.1098/rstb.2019.0555 |
| Rights: | https://royalsociety.org/-/media/journals/author/Licence-to-Publish-20062019-final.pdf ; https://royalsociety.org/journals/ethics-policies/data-sharing-mining/ |
| رقم الانضمام: | edsbas.AC9E9DA5 |
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