Academic Journal
No Association of nineteen COX-2 gene variants to preclinical markers of atherosclerosis The Cardiovascular Risk in Young Finns Study
| العنوان: | No Association of nineteen COX-2 gene variants to preclinical markers of atherosclerosis The Cardiovascular Risk in Young Finns Study |
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| المؤلفون: | Lähteelä, Katri, Kunnas, Tarja, Lyytikäinen, Leo-Pekka, Mononen, Nina, Taittonen, Leena, Laitinen, Tomi, Kettunen, Johannes, Juonala, Markus, Hutri-Kähönen, Nina, Kähönen, Mika, Viikari, Jorma S, Raitakari, Olli T, Lehtimäki, Terho, Nikkari, Seppo T |
| المساهمون: | Lääketieteen yksikkö - School of Medicine, University of Tampere |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Oikeuslääketiede ja muut lääketieteet - Forensic science and other medical sciences |
| الوصف: | Backgroud The role of cyclooxygenase-2 (COX-2) single nucleotide polymorphisms has mostly been studied in relation to advanced atherosclerosis, but little is known how they contribute to preclinical disease. In the present study we analyzed whether COX-2 gene variants associate independently with the early subclinical markers of atherosclerosis, carotid intima-media thickness and carotid artery distensibility in a population of young healthy Caucasian adults. Methods SNPs for association analysis were collected from the COX-2 gene and 5 kb up- and downstream of it. There were 19 SNPs available for analysis, four genotyped and fifteen imputed. Genotype data was available for 2442 individuals participating in the Cardiovascular Risk in Young Finns Study. Genotype imputation was performed using MACH 1.0 and HapMap II CEU (release 22) samples as reference. Association analysis was performed using linear regression with an additive model. PLINK was used for true genotyped SNPs and ProbABEL for imputed genotype dosages. False discovery rate was used to take into account multiple testing bias. Results Two of the COX-2 variants (rs689470, rs689462) associated with distensibility (p = 0.005) under the linear regression additive model. After adjustment with gender, age, body mass index and smoking status, association between these SNPs and distensibility remained significant (p = 0.031). Subjects carrying the minor alleles had higher value of carotid artery distensibility compared to the major allele homozygotes. However, after correcting p-values for multiple testing bias using false discovery rate, association was lost. Another COX-2 variant rs4648261 associated with mean carotid intima-media thickness (p = 0.046) and maximal carotid intima-media thickness (p = 0.048) in the linear regression model. Subjects carrying the minor allele of rs4648261 had lower values of mean and maximal carotid intima-media thickness compared to subjects homozygote for major allele. After adjustments the associations were lost with both ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | fulltext |
| اللغة: | English |
| تدمد: | 1471-2350 |
| Relation: | 32; BMC Medical Genetics; 13; https://trepo.tuni.fi/handle/10024/66330; URN:NBN:fi:uta-201209101034 |
| الاتاحة: | https://trepo.tuni.fi/handle/10024/66330 |
| Rights: | This publication is copyrighted. You may download, display and print it for Your own personal use. Commercial use is prohibited. ; openAccess |
| رقم الانضمام: | edsbas.AC5CE5FC |
| قاعدة البيانات: | BASE |
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